Fan E - Search Results

1

Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.

Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG. Bosch J, et al. Among authors: fan e. J Med Chem. 2006 Oct 5;49(20):5939-46. doi: 10.1021/jm060429m. J Med Chem. 2006. PMID: 17004709

2

Using a galactose library for exploration of a novel hydrophobic pocket in the receptor binding site of the Escherichia coli heat-labile enterotoxin.

Minke WE, Hong F, Verlinde CL, Hol WG, Fan E. Minke WE, et al. Among authors: fan e. J Biol Chem. 1999 Nov 19;274(47):33469-73. doi: 10.1074/jbc.274.47.33469. J Biol Chem. 1999. PMID: 10559230 Free article.

3

Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes.

Minke WE, Pickens J, Merritt EA, Fan E, Verlinde CL, Hol WG. Minke WE, et al. Among authors: fan e. Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):795-804. doi: 10.1107/s090744490000514x. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10930826

4

AB(5) toxins: structures and inhibitor design.

Fan E, Merritt EA, Verlinde CL, Hol WG. Fan E, et al. Curr Opin Struct Biol. 2000 Dec;10(6):680-6. doi: 10.1016/s0959-440x(00)00152-4. Curr Opin Struct Biol. 2000. PMID: 11114505 Review.

5

Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.

Fan E, Merritt EA, Zhang Z, Pickens JC, Roach C, Ahn M, Hol WG. Fan E, et al. Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):201-12. doi: 10.1107/s0907444900016814. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11173465

6

Solid-phase synthesis of N-acyl-N'-alkyl/aryl disubstituted guanidines.

Ghosh AK, Hol WG, Fan E. Ghosh AK, et al. Among authors: fan e. J Org Chem. 2001 Mar 23;66(6):2161-4. doi: 10.1021/jo001420+. J Org Chem. 2001. PMID: 11300917 No abstract available.

7

Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.

Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E. Pickens JC, et al. Among authors: fan e. Chem Biol. 2002 Feb;9(2):215-24. doi: 10.1016/s1074-5521(02)00097-2. Chem Biol. 2002. PMID: 11880036

8

Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.

Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WG, Fan E. Merritt EA, et al. Among authors: fan e. J Am Chem Soc. 2002 Jul 31;124(30):8818-24. doi: 10.1021/ja0202560. J Am Chem Soc. 2002. PMID: 12137534

9

Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.

Zhang Z, Merritt EA, Ahn M, Roach C, Hou Z, Verlinde CL, Hol WG, Fan E. Zhang Z, et al. Among authors: fan e. J Am Chem Soc. 2002 Nov 6;124(44):12991-8. doi: 10.1021/ja027584k. J Am Chem Soc. 2002. PMID: 12405825

10

Combating infectious diseases through multivalent design.

Fan E, Merritt EA. Fan E, et al. Curr Drug Targets Infect Disord. 2002 Jun;2(2):161-7. doi: 10.2174/1568005023342588. Curr Drug Targets Infect Disord. 2002. PMID: 12462146 Review.

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