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Hot-spot mimicry of a cytokine receptor by a small molecule.
Thanos CD, DeLano WL, Wells JA. Thanos CD, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7. doi: 10.1073/pnas.0607058103. Epub 2006 Oct 10. Proc Natl Acad Sci U S A. 2006. PMID: 17032757 Free PMC article.
Binding of small molecules to an adaptive protein-protein interface.
Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Arkin MR, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8. doi: 10.1073/pnas.252756299. Epub 2003 Feb 11. Proc Natl Acad Sci U S A. 2003. PMID: 12582206 Free PMC article.
Discovery of an allosteric site in the caspases.
Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Hardy JA, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12461-6. doi: 10.1073/pnas.0404781101. Epub 2004 Aug 16. Proc Natl Acad Sci U S A. 2004. PMID: 15314233 Free PMC article.
A common allosteric site and mechanism in caspases.
Scheer JM, Romanowski MJ, Wells JA. Scheer JM, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7595-600. doi: 10.1073/pnas.0602571103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682620 Free PMC article.
Two-state selection of conformation-specific antibodies.
Gao J, Sidhu SS, Wells JA. Gao J, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3071-6. doi: 10.1073/pnas.0812952106. Epub 2009 Feb 10. Proc Natl Acad Sci U S A. 2009. PMID: 19208804 Free PMC article.
516 results