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4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Bioorg Med Chem. 2007 Feb 15;15(4):1586-605. doi: 10.1016/j.bmc.2006.12.029. Epub 2006 Dec 20.
Bioorg Med Chem. 2007.
PMID: 17197188
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
Muchmore SW, Smith RA, Stewart AO, Cowart MD, Gomtsyan A, Matulenko MA, Yu H, Severin JM, Bhagwat SS, Lee CH, Kowaluk EA, Jarvis MF, Jakob CL.
Muchmore SW, et al. Among authors: jakob cl.
J Med Chem. 2006 Nov 16;49(23):6726-31. doi: 10.1021/jm060189a.
J Med Chem. 2006.
PMID: 17154503
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Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin.
Muchmore SW, Chen J, Jakob C, Zakula D, Matayoshi ED, Wu W, Zhang H, Li F, Ng SC, Altieri DC.
Muchmore SW, et al.
Mol Cell. 2000 Jul;6(1):173-82.
Mol Cell. 2000.
PMID: 10949038
Free article.
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Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.
von Geldern TW, Tu N, Kym PR, Link JT, Jae HS, Lai C, Apelqvist T, Rhonnstad P, Hagberg L, Koehler K, Grynfarb M, Goos-Nilsson A, Sandberg J, Osterlund M, Barkhem T, Höglund M, Wang J, Fung S, Wilcox D, Nguyen P, Jakob C, Hutchins C, Färnegårdh M, Kauppi B, Ohman L, Jacobson PB.
von Geldern TW, et al.
J Med Chem. 2004 Aug 12;47(17):4213-30. doi: 10.1021/jm0400045.
J Med Chem. 2004.
PMID: 15293993
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The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism.
Kauppi B, Jakob C, Färnegårdh M, Yang J, Ahola H, Alarcon M, Calles K, Engström O, Harlan J, Muchmore S, Ramqvist AK, Thorell S, Ohman L, Greer J, Gustafsson JA, Carlstedt-Duke J, Carlquist M.
Kauppi B, et al.
J Biol Chem. 2003 Jun 20;278(25):22748-54. doi: 10.1074/jbc.M212711200. Epub 2003 Apr 9.
J Biol Chem. 2003.
PMID: 12686538
Free article.
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