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The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells.
Ho KK, Rosivatz E, Gunn RM, Smith ME, Stavropoulou AV, Rosivatz E, Numbere MG, Wong JB, Lafitte VG, Behrendt JM, Myatt SS, Hailes HC, Woscholski R, Lam EW. Ho KK, et al. Among authors: lam ew. FEBS J. 2009 Aug;276(15):4037-50. doi: 10.1111/j.1742-4658.2009.07112.x. Epub 2009 Jun 22. FEBS J. 2009. PMID: 19549188 Free article.
Many forks in the path: cycling with FoxO.
Ho KK, Myatt SS, Lam EW. Ho KK, et al. Among authors: lam ew. Oncogene. 2008 Apr 7;27(16):2300-11. doi: 10.1038/onc.2008.23. Oncogene. 2008. PMID: 18391972 Review.
369 results