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Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ. Huth JR, et al. Among authors: richardson pl. Chem Biol Drug Des. 2007 Jul;70(1):1-12. doi: 10.1111/j.1747-0285.2007.00535.x. Chem Biol Drug Des. 2007. PMID: 17630989
Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery.
Stewart KD, Steffy K, Harris K, Harlan JE, Stoll VS, Huth JR, Walter KA, Gramling-Evans E, Mendoza RR, Severin JM, Richardson PL, Barrett LW, Matayoshi ED, Swift KM, Betz SF, Muchmore SW, Kempf DJ, Molla A. Stewart KD, et al. Among authors: richardson pl. J Comput Aided Mol Des. 2007 Jan-Mar;21(1-3):121-30. doi: 10.1007/s10822-007-9107-1. Epub 2007 Feb 9. J Comput Aided Mol Des. 2007. PMID: 17294246
Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.
Stewart KD, Huth JR, Ng TI, McDaniel K, Hutchinson RN, Stoll VS, Mendoza RR, Matayoshi ED, Carrick R, Mo H, Severin J, Walter K, Richardson PL, Barrett LW, Meadows R, Anderson S, Kohlbrenner W, Maring C, Kempf DJ, Molla A, Olejniczak ET. Stewart KD, et al. Among authors: richardson pl. Bioorg Med Chem Lett. 2010 Jan 15;20(2):612-7. doi: 10.1016/j.bmcl.2009.11.076. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20004576
Structural characterization of a soluble amyloid beta-peptide oligomer.
Yu L, Edalji R, Harlan JE, Holzman TF, Lopez AP, Labkovsky B, Hillen H, Barghorn S, Ebert U, Richardson PL, Miesbauer L, Solomon L, Bartley D, Walter K, Johnson RW, Hajduk PJ, Olejniczak ET. Yu L, et al. Among authors: richardson pl. Biochemistry. 2009 Mar 10;48(9):1870-7. doi: 10.1021/bi802046n. Biochemistry. 2009. PMID: 19216516
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Sun C, Song D, Davis-Taber RA, Barrett LW, Scott VE, Richardson PL, Pereda-Lopez A, Uchic ME, Solomon LR, Lake MR, Walter KA, Hajduk PJ, Olejniczak ET. Sun C, et al. Among authors: richardson pl. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7875-80. doi: 10.1073/pnas.0611397104. Epub 2007 Apr 30. Proc Natl Acad Sci U S A. 2007. PMID: 17470806 Free PMC article.
A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase.
Kage KL, Richardson PL, Traphagen L, Severin J, Pereda-Lopez A, Lubben T, Davis-Taber R, Vos MH, Bartley D, Walter K, Harlan J, Solomon L, Warrior U, Holzman TF, Faltynek C, Surowy CS, Scott VE. Kage KL, et al. Among authors: richardson pl. J Neurosci Methods. 2007 Mar 30;161(1):47-54. doi: 10.1016/j.jneumeth.2006.10.006. Epub 2006 Nov 2. J Neurosci Methods. 2007. PMID: 17083980
Species specificity of amidine-based urokinase inhibitors.
Klinghofer V, Stewart K, McGonigal T, Smith R, Sarthy A, Nienaber V, Butler C, Dorwin S, Richardson P, Weitzberg M, Wendt M, Rockway T, Zhao X, Hulkower KI, Giranda VL. Klinghofer V, et al. Biochemistry. 2001 Aug 7;40(31):9125-31. doi: 10.1021/bi010186u. Biochemistry. 2001. PMID: 11478879
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Goedken ER, Argiriadi MA, Dietrich JD, Petros AM, Krishnan N, Panchal SC, Qiu W, Wu H, Zhu H, Adams AM, Bodelle PM, Goguen L, Richardson PL, Slivka PF, Srikumaran M, Upadhyay AK, Wu B, Judge RA, Vasudevan A, Gopalakrishnan SM, Cox PB, Stoll VS, Sun C. Goedken ER, et al. Among authors: richardson pl. Sci Rep. 2022 Aug 26;12(1):14561. doi: 10.1038/s41598-022-18760-1. Sci Rep. 2022. PMID: 36028520 Free PMC article.
59 results