Hajduk PJ - Search Results

1

Toxicological evaluation of thiol-reactive compounds identified using a la assay to detect reactive molecules by nuclear magnetic resonance.

Huth JR, Song D, Mendoza RR, Black-Schaefer CL, Mack JC, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Hajduk PJ. Huth JR, et al. Among authors: hajduk pj. Chem Res Toxicol. 2007 Dec;20(12):1752-9. doi: 10.1021/tx700319t. Epub 2007 Nov 15. Chem Res Toxicol. 2007. PMID: 18001056

2

ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens.

Huth JR, Mendoza R, Olejniczak ET, Johnson RW, Cothron DA, Liu Y, Lerner CG, Chen J, Hajduk PJ. Huth JR, et al. Among authors: hajduk pj. J Am Chem Soc. 2005 Jan 12;127(1):217-24. doi: 10.1021/ja0455547. J Am Chem Soc. 2005. PMID: 15631471

3

Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups.

Metz JT, Huth JR, Hajduk PJ. Metz JT, et al. Among authors: hajduk pj. J Comput Aided Mol Des. 2007 Jan-Mar;21(1-3):139-44. doi: 10.1007/s10822-007-9109-z. Epub 2007 Mar 6. J Comput Aided Mol Des. 2007. PMID: 17340041

4

Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.

Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ. Huth JR, et al. Among authors: hajduk pj. Chem Biol Drug Des. 2007 Jul;70(1):1-12. doi: 10.1111/j.1747-0285.2007.00535.x. Chem Biol Drug Des. 2007. PMID: 17630989

5

A strategy for high-throughput assay development using leads derived from nuclear magnetic resonance-based screening.

Hajduk PJ, Betz SF, Mack J, Ruan X, Towne DL, Lerner CG, Beutel BA, Fesik SW. Hajduk PJ, et al. J Biomol Screen. 2002 Oct;7(5):429-32. doi: 10.1177/108705702237674. J Biomol Screen. 2002. PMID: 14599358

6

SOS-NMR: a saturation transfer NMR-based method for determining the structures of protein-ligand complexes.

Hajduk PJ, Mack JC, Olejniczak ET, Park C, Dandliker PJ, Beutel BA. Hajduk PJ, et al. J Am Chem Soc. 2004 Mar 3;126(8):2390-8. doi: 10.1021/ja039480v. J Am Chem Soc. 2004. PMID: 14982445

7

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ. Huth JR, et al. Among authors: hajduk pj. J Med Chem. 2004 Sep 23;47(20):4851-7. doi: 10.1021/jm0497803. J Med Chem. 2004. PMID: 15369388

8

Druggability indices for protein targets derived from NMR-based screening data.

Hajduk PJ, Huth JR, Fesik SW. Hajduk PJ, et al. J Med Chem. 2005 Apr 7;48(7):2518-25. doi: 10.1021/jm049131r. J Med Chem. 2005. PMID: 15801841

9

Utilization of NMR-derived fragment leads in drug design.

Huth JR, Sun C, Sauer DR, Hajduk PJ. Huth JR, et al. Among authors: hajduk pj. Methods Enzymol. 2005;394:549-71. doi: 10.1016/S0076-6879(05)94023-8. Methods Enzymol. 2005. PMID: 15808237

10

NMR in pharmacokinetic and pharmacodynamic profiling.

Sun C, Huth JR, Hajduk PJ. Sun C, et al. Among authors: hajduk pj. Chembiochem. 2005 Sep;6(9):1592-600. doi: 10.1002/cbic.200500028. Chembiochem. 2005. PMID: 16052607 Review. No abstract available.

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