Ladror US - Search Results

1

Toxicological evaluation of thiol-reactive compounds identified using a la assay to detect reactive molecules by nuclear magnetic resonance.

Huth JR, Song D, Mendoza RR, Black-Schaefer CL, Mack JC, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Hajduk PJ. Huth JR, et al. Among authors: ladror us. Chem Res Toxicol. 2007 Dec;20(12):1752-9. doi: 10.1021/tx700319t. Epub 2007 Nov 15. Chem Res Toxicol. 2007. PMID: 18001056

2

Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.

Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ. Huth JR, et al. Among authors: ladror us. Chem Biol Drug Des. 2007 Jul;70(1):1-12. doi: 10.1111/j.1747-0285.2007.00535.x. Chem Biol Drug Des. 2007. PMID: 17630989

3

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.

Petros AM, Huth JR, Oost T, Park CM, Ding H, Wang X, Zhang H, Nimmer P, Mendoza R, Sun C, Mack J, Walter K, Dorwin S, Gramling E, Ladror U, Rosenberg SH, Elmore SW, Fesik SW, Hajduk PJ. Petros AM, et al. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. doi: 10.1016/j.bmcl.2010.09.033. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20870405

4

Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design.

Digiammarino EL, Harlan JE, Walter KA, Ladror US, Edalji RP, Hutchins CW, Lake MR, Greischar AJ, Liu J, Ghayur T, Jakob CG. Digiammarino EL, et al. Among authors: ladror us. MAbs. 2011 Sep-Oct;3(5):487-94. doi: 10.4161/mabs.3.5.16326. Epub 2011 Sep 1. MAbs. 2011. PMID: 21814039 Free PMC article.

5

Domain structure analysis of elongation factor-3 from Saccharomyces cerevisiae by limited proteolysis and differential scanning calorimetry.

Ladror US, Egan DA, Snyder SW, Capobianco JO, Goldman RC, Dorwin SA, Johnson RW, Edalji R, Sarthy AV, McGonigal T, Walter KA, Holzman TF. Ladror US, et al. Protein Sci. 1998 Dec;7(12):2595-601. doi: 10.1002/pro.5560071213. Protein Sci. 1998. PMID: 9865954 Free PMC article.

6

Variants in Apaf-1 segregating with major depression promote apoptosome function.

Harlan J, Chen Y, Gubbins E, Mueller R, Roch JM, Walter K, Lake M, Olsen T, Metzger P, Dorwin S, Ladror U, Egan DA, Severin J, Johnson RW, Holzman TF, Voelp K, Davenport C, Beck A, Potter J, Gopalakrishnan M, Hahn A, Spear BB, Halbert DN, Sullivan JP, Abkevich V, Neff CD, Skolnick MH, Shattuck D, Katz DA. Harlan J, et al. Mol Psychiatry. 2006 Jan;11(1):76-85. doi: 10.1038/sj.mp.4001755. Mol Psychiatry. 2006. PMID: 16231040

7

Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.

Bussiere DE, Muchmore SW, Dealwis CG, Schluckebier G, Nienaber VL, Edalji RP, Walter KA, Ladror US, Holzman TF, Abad-Zapatero C. Bussiere DE, et al. Among authors: ladror us. Biochemistry. 1998 May 19;37(20):7103-12. doi: 10.1021/bi973113c. Biochemistry. 1998. PMID: 9585521

8

Cleavage of fluorogenic substrates for APP-processing proteases by human brain extracts. Ca(2+)-substrate interaction is responsible for Ca2+ stimulation of the neural protease activity.

Wang GT, Ladror US, Holzman TF, Klein WL, Krafft GA. Wang GT, et al. Among authors: ladror us. Mol Chem Neuropathol. 1994 Oct-Dec;23(2-3):191-9. doi: 10.1007/BF02815411. Mol Chem Neuropathol. 1994. PMID: 7702708

9

Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.

Liu X, Shi Y, Maag DX, Palma JP, Patterson MJ, Ellis PA, Surber BW, Ready DB, Soni NB, Ladror US, Xu AJ, Iyer R, Harlan JE, Solomon LR, Donawho CK, Penning TD, Johnson EF, Shoemaker AR. Liu X, et al. Among authors: ladror us. Clin Cancer Res. 2012 Jan 15;18(2):510-23. doi: 10.1158/1078-0432.CCR-11-1973. Epub 2011 Nov 29. Clin Cancer Res. 2012. PMID: 22128301

10

Driving affinity selection by centrifugal force.

Harlan JE, Egan DA, Ladror US, Snyder S, Tang MI, Buko A, Holzman TF. Harlan JE, et al. Among authors: ladror us. Assay Drug Dev Technol. 2003 Aug;1(4):507-19. doi: 10.1089/154065803322302763. Assay Drug Dev Technol. 2003. PMID: 15090247

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