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Development of dimeric modulators for anti-apoptotic Bcl-2 proteins.
Wang L, Kong F, Kokoski CL, Andrews DW, Xing C. Wang L, et al. Among authors: andrews dw. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40. doi: 10.1016/j.bmcl.2007.10.088. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 18023349 Free PMC article.
After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.
Ding J, Mooers BHM, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J. Ding J, et al. Among authors: andrews dw. J Biol Chem. 2014 Apr 25;289(17):11873-11896. doi: 10.1074/jbc.M114.552562. Epub 2014 Mar 10. J Biol Chem. 2014. PMID: 24616095 Free PMC article.
Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax.
Zhang Z, Lapolla SM, Annis MG, Truscott M, Roberts GJ, Miao Y, Shao Y, Tan C, Peng J, Johnson AE, Zhang XC, Andrews DW, Lin J. Zhang Z, et al. Among authors: andrews dw. J Biol Chem. 2004 Oct 15;279(42):43920-8. doi: 10.1074/jbc.M406412200. Epub 2004 Aug 9. J Biol Chem. 2004. PMID: 15302859 Free PMC article.
Mechanisms of action of Bcl-2 family proteins.
Shamas-Din A, Kale J, Leber B, Andrews DW. Shamas-Din A, et al. Among authors: andrews dw. Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a008714. doi: 10.1101/cshperspect.a008714. Cold Spring Harb Perspect Biol. 2013. PMID: 23545417 Free PMC article. Review.
294 results