Feng Y - Search Results

1

Integrating high-content screening and ligand-target prediction to identify mechanism of action.

Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. Young DW, et al. Among authors: feng y. Nat Chem Biol. 2008 Jan;4(1):59-68. doi: 10.1038/nchembio.2007.53. Epub 2007 Dec 9. Nat Chem Biol. 2008. PMID: 18066055

2

Phenotypic screening of small molecule libraries by high throughput cell imaging.

Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ. Yarrow JC, et al. Among authors: feng y. Comb Chem High Throughput Screen. 2003 Jun;6(4):279-86. doi: 10.2174/138620703106298527. Comb Chem High Throughput Screen. 2003. PMID: 12769670

3

Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression.

Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Venkatesh N, et al. Among authors: feng y. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8969-74. doi: 10.1073/pnas.0402803101. Epub 2004 Jun 7. Proc Natl Acad Sci U S A. 2004. PMID: 15184684 Free PMC article.

4

Multidimensional drug profiling by automated microscopy.

Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Perlman ZE, et al. Among authors: feng y. Science. 2004 Nov 12;306(5699):1194-8. doi: 10.1126/science.1100709. Science. 2004. PMID: 15539606

5

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T. Pelish HE, et al. Among authors: feng y. Nat Chem Biol. 2006 Jan;2(1):39-46. doi: 10.1038/nchembio751. Epub 2005 Nov 20. Nat Chem Biol. 2006. PMID: 16408091

6

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.

Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC. Wu Z, et al. Among authors: feng y. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84. doi: 10.1073/pnas.0606714103. Epub 2006 Sep 15. Proc Natl Acad Sci U S A. 2006. PMID: 16980408 Free PMC article.

7

A support vector machine classifier for recognizing mitotic subphases using high-content screening data.

Tao CY, Hoyt J, Feng Y. Tao CY, et al. Among authors: feng y. J Biomol Screen. 2007 Jun;12(4):490-6. doi: 10.1177/1087057107300707. Epub 2007 Apr 13. J Biomol Screen. 2007. PMID: 17435170

8

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.

Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Feng Y, et al. Nat Rev Drug Discov. 2009 Jul;8(7):567-78. doi: 10.1038/nrd2876. Nat Rev Drug Discov. 2009. PMID: 19568283 Review.

9

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.

Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F. Xie Y, et al. Among authors: feng y. J Biol Chem. 2013 Feb 1;288(5):2976-85. doi: 10.1074/jbc.M112.430066. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184937 Free PMC article.

10

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.

Cai X, Xu Y, Cheung AK, Tomlinson RC, Alcázar-Román A, Murphy L, Billich A, Zhang B, Feng Y, Klumpp M, Rondeau JM, Fazal AN, Wilson CJ, Myer V, Joberty G, Bouwmeester T, Labow MA, Finan PM, Porter JA, Ploegh HL, Baird D, De Camilli P, Tallarico JA, Huang Q. Cai X, et al. Among authors: feng y. Chem Biol. 2013 Jul 25;20(7):912-21. doi: 10.1016/j.chembiol.2013.05.010. Chem Biol. 2013. PMID: 23890009 Free PMC article.

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