Mitchison TJ - Search Results

1

Integrating high-content screening and ligand-target prediction to identify mechanism of action.

Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. Young DW, et al. Among authors: mitchison tj. Nat Chem Biol. 2008 Jan;4(1):59-68. doi: 10.1038/nchembio.2007.53. Epub 2007 Dec 9. Nat Chem Biol. 2008. PMID: 18066055

2

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.

Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Feng Y, et al. Among authors: mitchison tj. Nat Rev Drug Discov. 2009 Jul;8(7):567-78. doi: 10.1038/nrd2876. Nat Rev Drug Discov. 2009. PMID: 19568283 Review.

3

A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.

Koch PD, Miller HR, Yu G, Tallarico JA, Sorger PK, Wang Y, Feng Y, Thomas JR, Ross NT, Mitchison T. Koch PD, et al. ACS Chem Biol. 2018 Apr 20;13(4):1066-1081. doi: 10.1021/acschembio.7b01060. Epub 2018 Mar 19. ACS Chem Biol. 2018. PMID: 29553248 Free PMC article.

4

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.

Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW. Dorer RK, et al. Among authors: mitchison tj. Curr Biol. 2005 Jun 7;15(11):1070-6. doi: 10.1016/j.cub.2005.05.020. Curr Biol. 2005. PMID: 15936280 Free article.

5

Multidimensional drug profiling by automated microscopy.

Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Perlman ZE, et al. Among authors: mitchison tj. Science. 2004 Nov 12;306(5699):1194-8. doi: 10.1126/science.1100709. Science. 2004. PMID: 15539606

6

Phenotypic screening of small molecule libraries by high throughput cell imaging.

Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ. Yarrow JC, et al. Among authors: mitchison tj. Comb Chem High Throughput Screen. 2003 Jun;6(4):279-86. doi: 10.2174/138620703106298527. Comb Chem High Throughput Screen. 2003. PMID: 12769670

7

High-content screening and profiling of drug activity in an automated centrosome-duplication assay.

Perlman ZE, Mitchison TJ, Mayer TU. Perlman ZE, et al. Among authors: mitchison tj. Chembiochem. 2005 Jan;6(1):145-51. doi: 10.1002/cbic.200400266. Chembiochem. 2005. PMID: 15568197

8

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.

Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Degterev A, et al. Among authors: mitchison tj. Nat Chem Biol. 2005 Jul;1(2):112-9. doi: 10.1038/nchembio711. Epub 2005 May 29. Nat Chem Biol. 2005. PMID: 16408008

9

In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.

Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ. Chittajallu DR, et al. Among authors: mitchison tj. Nat Methods. 2015 Jun;12(6):577-85. doi: 10.1038/nmeth.3363. Epub 2015 Apr 13. Nat Methods. 2015. PMID: 25867850 Free PMC article.

10

Noble metals strip peptides from class II MHC proteins.

De Wall SL, Painter C, Stone JD, Bandaranayake R, Wiley DC, Mitchison TJ, Stern LJ, DeDecker BS. De Wall SL, et al. Among authors: mitchison tj. Nat Chem Biol. 2006 Apr;2(4):197-201. doi: 10.1038/nchembio773. Epub 2006 Feb 26. Nat Chem Biol. 2006. PMID: 16505807

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