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Blockade of CD11a by efalizumab in psoriasis patients induces a unique state of T-cell hyporesponsiveness.
Guttman-Yassky E, Vugmeyster Y, Lowes MA, Chamian F, Kikuchi T, Kagen M, Gilleaudeau P, Lee E, Hunte B, Howell K, Dummer W, Bodary SC, Krueger JG. Guttman-Yassky E, et al. Among authors: dummer w. J Invest Dermatol. 2008 May;128(5):1182-91. doi: 10.1038/jid.2008.4. Epub 2008 Jan 31. J Invest Dermatol. 2008. PMID: 18239614 Free article. Clinical Trial.
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).
Lowes MA, Chamian F, Abello MV, Fuentes-Duculan J, Lin SL, Nussbaum R, Novitskaya I, Carbonaro H, Cardinale I, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Wittkowski KM, Papp K, Garovoy M, Dummer W, Steinman RM, Krueger JG. Lowes MA, et al. Among authors: dummer w. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19057-62. doi: 10.1073/pnas.0509736102. Proc Natl Acad Sci U S A. 2005. PMID: 16380428 Free PMC article.
A novel targeted T-cell modulator, efalizumab, for plaque psoriasis.
Lebwohl M, Tyring SK, Hamilton TK, Toth D, Glazer S, Tawfik NH, Walicke P, Dummer W, Wang X, Garovoy MR, Pariser D; Efalizumab Study Group. Lebwohl M, et al. Among authors: dummer w. N Engl J Med. 2003 Nov 20;349(21):2004-13. doi: 10.1056/NEJMoa030002. N Engl J Med. 2003. PMID: 14627785 Free article. Clinical Trial.
59 results