Siemers ER - Search Results

1

Partnership between academia and industry for drug discovery in Alzheimer's disease.

Ivinson AJ, Lane R, May PC, Hosford DA, Carrillo MC, Siemers ER. Ivinson AJ, et al. Among authors: siemers er. Alzheimers Dement. 2008 Mar;4(2):80-8. doi: 10.1016/j.jalz.2008.02.004. Alzheimers Dement. 2008. PMID: 18631952

2

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Siemers ER, et al. Neurology. 2006 Feb 28;66(4):602-4. doi: 10.1212/01.WNL.0000198762.41312.E1. Neurology. 2006. PMID: 16505324 Clinical Trial.

3

New pathways in drug discovery for Alzheimer's disease.

Siemers ER, Dean RA, Demattos R, May PC. Siemers ER, et al. Curr Neurol Neurosci Rep. 2006 Sep;6(5):372-8. doi: 10.1007/s11910-996-0017-8. Curr Neurol Neurosci Rep. 2006. PMID: 16928346 Review.

4

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase.

Siemers ER, Dean RA, Friedrich S, Ferguson-Sells L, Gonzales C, Farlow MR, May PC. Siemers ER, et al. Clin Neuropharmacol. 2007 Nov-Dec;30(6):317-25. doi: 10.1097/WNF.0b013e31805b7660. Clin Neuropharmacol. 2007. PMID: 18090456 Clinical Trial.

5

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.

Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, Demattos RB, May PC, Paul SM, Holtzman DM. Bateman RJ, et al. Among authors: siemers er. Ann Neurol. 2009 Jul;66(1):48-54. doi: 10.1002/ana.21623. Ann Neurol. 2009. PMID: 19360898 Free PMC article. Clinical Trial.

6

Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease.

Henley DB, May PC, Dean RA, Siemers ER. Henley DB, et al. Among authors: siemers er. Expert Opin Pharmacother. 2009 Jul;10(10):1657-64. doi: 10.1517/14656560903044982. Expert Opin Pharmacother. 2009. PMID: 19527190 Review.

7

Developing a national strategy to prevent dementia: Leon Thal Symposium 2009.

Khachaturian ZS, Barnes D, Einstein R, Johnson S, Lee V, Roses A, Sager MA, Shankle WR, Snyder PJ, Petersen RC, Schellenberg G, Trojanowski J, Aisen P, Albert MS, Breitner JC, Buckholtz N, Carrillo M, Ferris S, Greenberg BD, Grundman M, Khachaturian AS, Kuller LH, Lopez OL, Maruff P, Mohs RC, Morrison-Bogorad M, Phelps C, Reiman E, Sabbagh M, Sano M, Schneider LS, Siemers E, Tariot P, Touchon J, Vellas B, Bain LJ. Khachaturian ZS, et al. Alzheimers Dement. 2010 Mar;6(2):89-97. doi: 10.1016/j.jalz.2010.01.008. Alzheimers Dement. 2010. PMID: 20298968 Free PMC article.

8

Role of biochemical Alzheimer's disease biomarkers as end points in clinical trials.

Siemers E, DeMattos RB, May PC, Dean RA. Siemers E, et al. Biomark Med. 2010 Feb;4(1):81-9. doi: 10.2217/bmm.09.85. Biomark Med. 2010. PMID: 20387304 Review.

9

The Alzheimer's disease neuroimaging initiative: perspectives of the Industry Scientific Advisory Board.

Schmidt ME, Siemers E, Snyder PJ, Potter WZ, Cole P, Soares H. Schmidt ME, et al. Alzheimers Dement. 2010 May;6(3):286-90. doi: 10.1016/j.jalz.2010.03.010. Alzheimers Dement. 2010. PMID: 20451878

10

Biomarkers for Alzheimer's disease therapeutic trials.

Hampel H, Wilcock G, Andrieu S, Aisen P, Blennow K, Broich K, Carrillo M, Fox NC, Frisoni GB, Isaac M, Lovestone S, Nordberg A, Prvulovic D, Sampaio C, Scheltens P, Weiner M, Winblad B, Coley N, Vellas B; Oxford Task Force Group. Hampel H, et al. Prog Neurobiol. 2011 Dec;95(4):579-93. doi: 10.1016/j.pneurobio.2010.11.005. Epub 2010 Dec 2. Prog Neurobiol. 2011. PMID: 21130138 Review.

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