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Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.
Stewart KD, Huth JR, Ng TI, McDaniel K, Hutchinson RN, Stoll VS, Mendoza RR, Matayoshi ED, Carrick R, Mo H, Severin J, Walter K, Richardson PL, Barrett LW, Meadows R, Anderson S, Kohlbrenner W, Maring C, Kempf DJ, Molla A, Olejniczak ET. Stewart KD, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):612-7. doi: 10.1016/j.bmcl.2009.11.076. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20004576
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W Jr, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: stewart kd. J Med Chem. 1996 Jan 19;39(2):392-7. doi: 10.1021/jm9507183. J Med Chem. 1996. PMID: 8558507
ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease.
Sham HL, Kempf DJ, Molla A, Marsh KC, Kumar GN, Chen CM, Kati W, Stewart K, Lal R, Hsu A, Betebenner D, Korneyeva M, Vasavanonda S, McDonald E, Saldivar A, Wideburg N, Chen X, Niu P, Park C, Jayanti V, Grabowski B, Granneman GR, Sun E, Japour AJ, Leonard JM, Plattner JJ, Norbeck DW. Sham HL, et al. Antimicrob Agents Chemother. 1998 Dec;42(12):3218-24. doi: 10.1128/AAC.42.12.3218. Antimicrob Agents Chemother. 1998. PMID: 9835517 Free PMC article. Clinical Trial.
145 results