Huth JR - Search Results

1

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.

Petros AM, Huth JR, Oost T, Park CM, Ding H, Wang X, Zhang H, Nimmer P, Mendoza R, Sun C, Mack J, Walter K, Dorwin S, Gramling E, Ladror U, Rosenberg SH, Elmore SW, Fesik SW, Hajduk PJ. Petros AM, et al. Among authors: huth jr. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. doi: 10.1016/j.bmcl.2010.09.033. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20870405

2

Utility of NMR in lead optimization: fragment-based approaches.

Huth JR, Sun C. Huth JR, et al. Comb Chem High Throughput Screen. 2002 Dec;5(8):631-43. doi: 10.2174/1386207023329941. Comb Chem High Throughput Screen. 2002. PMID: 12470260 Review.

3

Druggability indices for protein targets derived from NMR-based screening data.

Hajduk PJ, Huth JR, Fesik SW. Hajduk PJ, et al. Among authors: huth jr. J Med Chem. 2005 Apr 7;48(7):2518-25. doi: 10.1021/jm049131r. J Med Chem. 2005. PMID: 15801841

4

Utilization of NMR-derived fragment leads in drug design.

Huth JR, Sun C, Sauer DR, Hajduk PJ. Huth JR, et al. Methods Enzymol. 2005;394:549-71. doi: 10.1016/S0076-6879(05)94023-8. Methods Enzymol. 2005. PMID: 15808237

5

Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.

Stewart KD, Huth JR, Ng TI, McDaniel K, Hutchinson RN, Stoll VS, Mendoza RR, Matayoshi ED, Carrick R, Mo H, Severin J, Walter K, Richardson PL, Barrett LW, Meadows R, Anderson S, Kohlbrenner W, Maring C, Kempf DJ, Molla A, Olejniczak ET. Stewart KD, et al. Among authors: huth jr. Bioorg Med Chem Lett. 2010 Jan 15;20(2):612-7. doi: 10.1016/j.bmcl.2009.11.076. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20004576

6

N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.

Bruncko M, Tahir SK, Song X, Chen J, Ding H, Huth JR, Jin S, Judge RA, Madar DJ, Park CH, Park CM, Petros AM, Tse C, Rosenberg SH, Elmore SW. Bruncko M, et al. Among authors: huth jr. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7503-6. doi: 10.1016/j.bmcl.2010.10.010. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2010. PMID: 21106457

7

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms.

Qian J, Voorbach MJ, Huth JR, Coen ML, Zhang H, Ng SC, Comess KM, Petros AM, Rosenberg SH, Warrior U, Burns DJ. Qian J, et al. Among authors: huth jr. Anal Biochem. 2004 May 15;328(2):131-8. doi: 10.1016/j.ab.2003.12.034. Anal Biochem. 2004. PMID: 15113688

8

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ. Huth JR, et al. J Med Chem. 2004 Sep 23;47(20):4851-7. doi: 10.1021/jm0497803. J Med Chem. 2004. PMID: 15369388

9

NMR in pharmacokinetic and pharmacodynamic profiling.

Sun C, Huth JR, Hajduk PJ. Sun C, et al. Among authors: huth jr. Chembiochem. 2005 Sep;6(9):1592-600. doi: 10.1002/cbic.200500028. Chembiochem. 2005. PMID: 16052607 Review. No abstract available.

10

Enhancement of chemical rules for predicting compound reactivity towards protein thiol groups.

Metz JT, Huth JR, Hajduk PJ. Metz JT, et al. Among authors: huth jr. J Comput Aided Mol Des. 2007 Jan-Mar;21(1-3):139-44. doi: 10.1007/s10822-007-9109-z. Epub 2007 Mar 6. J Comput Aided Mol Des. 2007. PMID: 17340041

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