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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.
Leukemia. 2013 Feb;27(2):430-40. doi: 10.1038/leu.2012.183. Epub 2012 Jul 5.
Leukemia. 2013.
PMID: 22763387
Free PMC article.
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.
Heller E, Hurchla MA, Xiang J, Su X, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior JL, Piwnica-Worms D, Long F, Cagan R, Weilbaecher KN.
Heller E, et al. Among authors: hornick mc.
Cancer Res. 2012 Feb 15;72(4):897-907. doi: 10.1158/0008-5472.CAN-11-2681. Epub 2011 Dec 20.
Cancer Res. 2012.
PMID: 22186138
Free PMC article.
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Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer.
Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D.
Garg G, et al.
Mol Cancer. 2014 Mar 7;13:50. doi: 10.1186/1476-4598-13-50.
Mol Cancer. 2014.
PMID: 24602489
Free PMC article.
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Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.
Hashim YM, Spitzer D, Vangveravong S, Hornick MC, Garg G, Hornick JR, Goedegebuure P, Mach RH, Hawkins WG.
Hashim YM, et al. Among authors: hornick mc.
Mol Oncol. 2014 Jul;8(5):956-67. doi: 10.1016/j.molonc.2014.03.005. Epub 2014 Mar 26.
Mol Oncol. 2014.
PMID: 24731702
Free PMC article.
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Transgene expression in a model of composite tissue allotransplantation.
Cooney DS, Chambers CB, Suchy H, Hornick MC, Reichensperger J, Neumeister MW.
Cooney DS, et al. Among authors: hornick mc.
Plast Reconstr Surg. 2010 Mar;125(3):837-45. doi: 10.1097/PRS.0b013e3181cb6389.
Plast Reconstr Surg. 2010.
PMID: 20009792
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