Lightfoot HL - Search Results

1

Target mRNA inhibition by oligonucleotide drugs in man.

Lightfoot HL, Hall J. Lightfoot HL, et al. Nucleic Acids Res. 2012 Nov;40(21):10585-95. doi: 10.1093/nar/gks861. Epub 2012 Sep 18. Nucleic Acids Res. 2012. PMID: 22989709 Free PMC article.

2

Endogenous polyamine function--the RNA perspective.

Lightfoot HL, Hall J. Lightfoot HL, et al. Nucleic Acids Res. 2014 Oct;42(18):11275-90. doi: 10.1093/nar/gku837. Epub 2014 Sep 17. Nucleic Acids Res. 2014. PMID: 25232095 Free PMC article. Review.

3

Polyamine-oligonucleotide conjugates: a promising direction for nucleic acid tools and therapeutics.

Menzi M, Lightfoot HL, Hall J. Menzi M, et al. Among authors: lightfoot hl. Future Med Chem. 2015;7(13):1733-49. doi: 10.4155/fmc.15.90. Epub 2015 Oct 1. Future Med Chem. 2015. PMID: 26424049 Review.

4

Synthesis and cellular activity of stereochemically-pure 2'-O-(2-methoxyethyl)-phosphorothioate oligonucleotides.

Li M, Lightfoot HL, Halloy F, Malinowska AL, Berk C, Behera A, Schümperli D, Hall J. Li M, et al. Among authors: lightfoot hl. Chem Commun (Camb). 2017 Jan 3;53(3):541-544. doi: 10.1039/c6cc08473g. Chem Commun (Camb). 2017. PMID: 27966701

5

Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans.

Subasic D, Brümmer A, Wu Y, Pinto SM, Imig J, Keller M, Jovanovic M, Lightfoot HL, Nasso S, Goetze S, Brunner E, Hall J, Aebersold R, Zavolan M, Hengartner MO. Subasic D, et al. Among authors: lightfoot hl. Genome Res. 2015 Nov;25(11):1680-91. doi: 10.1101/gr.183160.114. Epub 2015 Jul 31. Genome Res. 2015. PMID: 26232411 Free PMC article.

6

Control of the polyamine biosynthesis pathway by G₂-quadruplexes.

Lightfoot HL, Hagen T, Cléry A, Allain FH, Hall J. Lightfoot HL, et al. Elife. 2018 Jul 31;7:e36362. doi: 10.7554/eLife.36362. Elife. 2018. PMID: 30063205 Free PMC article.

7

The diverse structural landscape of quadruplexes.

Lightfoot HL, Hagen T, Tatum NJ, Hall J. Lightfoot HL, et al. FEBS Lett. 2019 Aug;593(16):2083-2102. doi: 10.1002/1873-3468.13547. Epub 2019 Jul 30. FEBS Lett. 2019. PMID: 31325371 Free article. Review.

8

Towards Improved Oligonucleotide Therapeutics Through Faster Target Binding Kinetics.

Menzi M, Wild B, Pradère U, Malinowska AL, Brunschweiger A, Lightfoot HL, Hall J. Menzi M, et al. Among authors: lightfoot hl. Chemistry. 2017 Oct 12;23(57):14221-14230. doi: 10.1002/chem.201701670. Epub 2017 Sep 12. Chemistry. 2017. PMID: 28746731

9

Site-Specific Fluorophore Labeling of Guanosines in RNA G-Quadruplexes.

Hagen T, Malinowska AL, Lightfoot HL, Bigatti M, Hall J. Hagen T, et al. Among authors: lightfoot hl. ACS Omega. 2019 May 14;4(5):8472-8479. doi: 10.1021/acsomega.9b00704. eCollection 2019 May 31. ACS Omega. 2019. PMID: 31459936 Free PMC article.

10

Evolution of Small Molecule Kinase Drugs.

Lightfoot HL, Goldberg FW, Sedelmeier J. Lightfoot HL, et al. ACS Med Chem Lett. 2018 Dec 18;10(2):153-160. doi: 10.1021/acsmedchemlett.8b00445. eCollection 2019 Feb 14. ACS Med Chem Lett. 2018. PMID: 30783496 Free PMC article.

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