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The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex.
Zhu AZ, Renner CC, Hatsukami DK, Swan GE, Lerman C, Benowitz NL, Tyndale RF. Zhu AZ, et al. Among authors: tyndale rf. Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):708-18. doi: 10.1158/1055-9965.EPI-12-1234-T. Epub 2013 Jan 31. Cancer Epidemiol Biomarkers Prev. 2013. PMID: 23371292 Free PMC article.
Deficient C-oxidation of nicotine continued.
Benowitz NL, Griffin C, Tyndale R. Benowitz NL, et al. Clin Pharmacol Ther. 2001 Dec;70(6):567. doi: 10.1067/mcp.2001.120252. Clin Pharmacol Ther. 2001. PMID: 11753274 No abstract available.
A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.
Tyndale RF, Pianezza ML, Sellers EM. Tyndale RF, et al. Nicotine Tob Res. 1999;1 Suppl 2:S63-7; discussion S69-70. doi: 10.1080/14622299050011831. Nicotine Tob Res. 1999. PMID: 11768189 Review.
This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if dependent, how impairment of the CYP2A6 gene function decreases the number of cigarettes consumed by smokers (Pianezza M, Sellers EM, Tyndale …
This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if depend …
441 results