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PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration.
Bioorg Med Chem Lett. 2013 Jul 15;23(14):4117-9. doi: 10.1016/j.bmcl.2013.05.048. Epub 2013 May 24.
Bioorg Med Chem Lett. 2013.
PMID: 23743283
Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model.
Semko CM, Chen L, Dressen DB, Dreyer ML, Dunn W, Farouz FS, Freedman SB, Holsztynska EJ, Jefferies M, Konradi AW, Liao A, Lugar J, Mutter L, Pleiss MA, Quinn KP, Thompson T, Thorsett ED, Vandevert C, Xu YZ, Yednock TA.
Semko CM, et al. Among authors: vandevert c.
Bioorg Med Chem Lett. 2011 Mar 15;21(6):1741-3. doi: 10.1016/j.bmcl.2011.01.075. Epub 2011 Jan 22.
Bioorg Med Chem Lett. 2011.
PMID: 21316228
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Orally available and efficacious α4β1/α4β7 integrin inhibitors.
Xu YZ, Smith JL, Semko CM, Rossiter KI, Fukuda JY, Dappen MS, Quincy DA, Konradi AW, Mao W, Welch B, Dreyer ML, Samant B, Zhang H, Lugar J, Liao Z, Henschel C, Petersen E, Vandevert C, Shoemaker M, Wehner N, Mutter L, Shopp G, Krimm M, Chen L, Wipke B, Dofiles L, Gallager I, Sauer JM, Messersmith EK, Pleiss MA, Bard F, Yednock TA.
Xu YZ, et al. Among authors: vandevert c.
Bioorg Med Chem Lett. 2013 Aug 1;23(15):4370-3. doi: 10.1016/j.bmcl.2013.05.076. Epub 2013 May 31.
Bioorg Med Chem Lett. 2013.
PMID: 23777782
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Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand.
Yednock TA, Cannon C, Vandevert C, Goldbach EG, Shaw G, Ellis DK, Liaw C, Fritz LC, Tanner LI.
Yednock TA, et al. Among authors: vandevert c.
J Biol Chem. 1995 Dec 1;270(48):28740-50. doi: 10.1074/jbc.270.48.28740.
J Biol Chem. 1995.
PMID: 7499396
Free article.
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Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.
Flanagan K, Fitzgerald K, Baker J, Regnstrom K, Gardai S, Bard F, Mocci S, Seto P, You M, Larochelle C, Prat A, Chow S, Li L, Vandevert C, Zago W, Lorenzana C, Nishioka C, Hoffman J, Botelho R, Willits C, Tanaka K, Johnston J, Yednock T.
Flanagan K, et al. Among authors: vandevert c.
PLoS One. 2012;7(7):e40443. doi: 10.1371/journal.pone.0040443. Epub 2012 Jul 6.
PLoS One. 2012.
PMID: 22792325
Free PMC article.
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Prolonged reversal of chronic experimental allergic encephalomyelitis using a small molecule inhibitor of alpha4 integrin.
Piraino PS, Yednock TA, Freedman SB, Messersmith EK, Pleiss MA, Vandevert C, Thorsett ED, Karlik SJ.
Piraino PS, et al. Among authors: vandevert c.
J Neuroimmunol. 2002 Oct;131(1-2):147-59. doi: 10.1016/s0165-5728(02)00273-4.
J Neuroimmunol. 2002.
PMID: 12458046
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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P.
Schenk D, et al. Among authors: vandevert c.
Nature. 1999 Jul 8;400(6740):173-7. doi: 10.1038/22124.
Nature. 1999.
PMID: 10408445
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