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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Nature. 2013 Nov 28;503(7477):548-51. doi: 10.1038/nature12796. Epub 2013 Nov 20.
Nature. 2013.
PMID: 24256730
Free PMC article.
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design.
Ostrem JM, Shokat KM.
Ostrem JM, et al.
Nat Rev Drug Discov. 2016 Nov;15(11):771-785. doi: 10.1038/nrd.2016.139. Epub 2016 Jul 29.
Nat Rev Drug Discov. 2016.
PMID: 27469033
Review.
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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM.
Chen L, et al.
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas.1314939111. Epub 2014 Jun 24.
Proc Natl Acad Sci U S A. 2014.
PMID: 24961373
Free PMC article.
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A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.
Schroeder CM, Ostrem JM, Hertz NT, Vale RD.
Schroeder CM, et al. Among authors: ostrem jm.
Elife. 2014 Oct 1;3:e03351. doi: 10.7554/eLife.03351.
Elife. 2014.
PMID: 25272277
Free PMC article.
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Overcoming KRAS-Mutant Lung Cancer.
Luo J, Ostrem J, Pellini B, Imbody D, Stern Y, Solanki HS, Haura EB, Villaruz LC.
Luo J, et al.
Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-11. doi: 10.1200/EDBK_360354.
Am Soc Clin Oncol Educ Book. 2022.
PMID: 35412860
Free article.
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Highly specific intracellular ubiquitination of a small molecule.
Li W, Garcia-Rivera EM, Mitchell DC, Chick JM, Maetani M, Knapp JM, Matthews GM, Shirasaki R, de Matos Simoes R, Viswanathan V, Pulice JL, Rees MG, Roth JA, Gygi SP, Mitsiades CS, Kadoch C, Schreiber SL, Ostrem JML.
Li W, et al. Among authors: ostrem jml.
bioRxiv [Preprint]. 2024 Jan 28:2024.01.26.577493. doi: 10.1101/2024.01.26.577493.
bioRxiv. 2024.
PMID: 38328167
Free PMC article.
Preprint.
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Rational Screening for Cooperativity in Small-Molecule Inducers of Protein-Protein Associations.
Liu S, Tong B, Mason JW, Ostrem JM, Tutter A, Hua BK, Tang SA, Bonazzi S, Briner K, Berst F, Zécri FJ, Schreiber SL.
Liu S, et al. Among authors: ostrem jm.
J Am Chem Soc. 2023 Oct 25;145(42):23281-23291. doi: 10.1021/jacs.3c08307. Epub 2023 Oct 10.
J Am Chem Soc. 2023.
PMID: 37816014
Free PMC article.
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Rational screening for cooperativity in small-molecule inducers of protein-protein associations.
Liu S, Tong B, Mason JW, Ostrem JM, Tutter A, Hua BK, Tang SA, Bonazzi S, Briner K, Berst F, Zécri FJ, Schreiber SL.
Liu S, et al. Among authors: ostrem jm.
bioRxiv [Preprint]. 2023 May 24:2023.05.22.541439. doi: 10.1101/2023.05.22.541439.
bioRxiv. 2023.
PMID: 37292909
Free PMC article.
Updated.
Preprint.
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