Wells JA - Search Results

1

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. Ostrem JM, et al. Among authors: wells ja. Nature. 2013 Nov 28;503(7477):548-51. doi: 10.1038/nature12796. Epub 2013 Nov 20. Nature. 2013. PMID: 24256730 Free PMC article.

2

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.

Arkin MR, Wells JA. Arkin MR, et al. Among authors: wells ja. Nat Rev Drug Discov. 2004 Apr;3(4):301-17. doi: 10.1038/nrd1343. Nat Rev Drug Discov. 2004. PMID: 15060526 Review. No abstract available.

3

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

Wells JA, McClendon CL. Wells JA, et al. Nature. 2007 Dec 13;450(7172):1001-9. doi: 10.1038/nature06526. Nature. 2007. PMID: 18075579 Review.

4

Turning enzymes ON with small molecules.

Zorn JA, Wells JA. Zorn JA, et al. Among authors: wells ja. Nat Chem Biol. 2010 Mar;6(3):179-188. doi: 10.1038/nchembio.318. Nat Chem Biol. 2010. PMID: 20154666

5

Turning a protein kinase on or off from a single allosteric site via disulfide trapping.

Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. Sadowsky JD, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6056-61. doi: 10.1073/pnas.1102376108. Epub 2011 Mar 23. Proc Natl Acad Sci U S A. 2011. PMID: 21430264 Free PMC article.

6

Nature-inspired design of motif-specific antibody scaffolds.

Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. Koerber JT, et al. Among authors: wells ja. Nat Biotechnol. 2013 Oct;31(10):916-21. doi: 10.1038/nbt.2672. Epub 2013 Aug 18. Nat Biotechnol. 2013. PMID: 23955275 Free PMC article.

7

Unraveling the mechanism of cell death induced by chemical fibrils.

Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Julien O, et al. Among authors: wells ja. Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28. Nat Chem Biol. 2014. PMID: 25262416 Free PMC article.

8

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. Rettenmaier TJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17. Proc Natl Acad Sci U S A. 2014. PMID: 25518860 Free PMC article.

9

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. Nguyen DP, et al. Among authors: wells ja. Nat Commun. 2016 Jul 1;7:12009. doi: 10.1038/ncomms12009. Nat Commun. 2016. PMID: 27363581 Free PMC article.

10

Enzyme-catalyzed expressed protein ligation.

Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. Henager SH, et al. Nat Methods. 2016 Nov;13(11):925-927. doi: 10.1038/nmeth.4004. Epub 2016 Sep 26. Nat Methods. 2016. PMID: 27669326 Free PMC article.

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