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Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound.
Zhang H, Neimanis S, Lopez-Garcia LA, Arencibia JM, Amon S, Stroba A, Zeuzem S, Proschak E, Stark H, Bauer AF, Busschots K, Jørgensen TJ, Engel M, Schulze JO, Biondi RM. Zhang H, et al. Among authors: busschots k. Chem Biol. 2014 Jun 19;21(6):754-65. doi: 10.1016/j.chembiol.2014.04.007. Epub 2014 May 15. Chem Biol. 2014. PMID: 24836908
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Schulze JO, Saladino G, Busschots K, Neimanis S, Süß E, Odadzic D, Zeuzem S, Hindie V, Herbrand AK, Lisa MN, Alzari PM, Gervasio FL, Biondi RM. Schulze JO, et al. Among authors: busschots k. Cell Chem Biol. 2016 Oct 20;23(10):1193-1205. doi: 10.1016/j.chembiol.2016.06.017. Epub 2016 Sep 29. Cell Chem Biol. 2016. PMID: 27693059 Free article.
Identification of the LEDGF/p75 binding site in HIV-1 integrase.
Busschots K, Voet A, De Maeyer M, Rain JC, Emiliani S, Benarous R, Desender L, Debyser Z, Christ F. Busschots K, et al. J Mol Biol. 2007 Feb 2;365(5):1480-92. doi: 10.1016/j.jmb.2006.10.094. Epub 2006 Nov 3. J Mol Biol. 2007. PMID: 17137594
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.
Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z. Busschots K, et al. J Biol Chem. 2005 May 6;280(18):17841-7. doi: 10.1074/jbc.M411681200. Epub 2005 Mar 4. J Biol Chem. 2005. PMID: 15749713 Free article.
Chem. 278, 372-381; Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., De Clercq, E., Debyser, Z., and Engelborghs, Y. (2003) J. ...
Chem. 278, 372-381; Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., De Clercq, E., Debyser, Z., and Engelborghs, Y. …
15 results