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Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator.
Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, Ehrler JHM, Hiesinger K, Thavam S, Janning P, Sievers S, Knapp S, Proschak E, Ziegler S, Waldmann H. Dötsch L, et al. Among authors: proschak e. J Med Chem. 2024 Mar 28;67(6):4691-4706. doi: 10.1021/acs.jmedchem.3c02245. Epub 2024 Mar 12. J Med Chem. 2024. PMID: 38470246 Free PMC article.
Photochemistry in Medicinal Chemistry and Chemical Biology.
Zhu WF, Empel C, Pelliccia S, Koenigs RM, Proschak E, Hernandez-Olmos V. Zhu WF, et al. Among authors: proschak e. J Med Chem. 2024 Mar 28;67(6):4322-4345. doi: 10.1021/acs.jmedchem.3c02109. Epub 2024 Mar 8. J Med Chem. 2024. PMID: 38457829 Review.
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Balzulat A, Zhu WF, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, Dubiel M, Frank A, Menge A, Hebchen M, Metzner K, Lu R, Lukowski R, Ruth P, Knapp S, Müller S, Steinhilber D, Hänelt I, Stark H, Proschak E, Schmidtko A. Balzulat A, et al. Among authors: proschak e. Adv Sci (Weinh). 2024 Apr;11(15):e2307237. doi: 10.1002/advs.202307237. Epub 2024 Feb 13. Adv Sci (Weinh). 2024. PMID: 38350720 Free PMC article.
Photosensitization enables Pauson-Khand-type reactions with nitrenes.
Li F, Zhu WF, Empel C, Datsenko O, Kumar A, Xu Y, Ehrler JHM, Atodiresei I, Knapp S, Mykhailiuk PK, Proschak E, Koenigs RM. Li F, et al. Among authors: proschak e. Science. 2024 Feb 2;383(6682):498-503. doi: 10.1126/science.adm8095. Epub 2024 Feb 1. Science. 2024. PMID: 38301027
Compilation and evaluation of a fatty acid mimetics screening library.
Ehrler JHM, Brunst S, Tjaden A, Kilu W, Heering J, Hernandez-Olmos V, Krommes A, Kramer JS, Steinhilber D, Schubert-Zsilavecz M, Müller S, Merk D, Proschak E. Ehrler JHM, et al. Among authors: proschak e. Biochem Pharmacol. 2022 Oct;204:115191. doi: 10.1016/j.bcp.2022.115191. Epub 2022 Jul 27. Biochem Pharmacol. 2022. PMID: 35907497
161 results