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Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.
Vargas-Inchaustegui DA, Tuero I, Mohanram V, Musich T, Pegu P, Valentin A, Sui Y, Rosati M, Bear J, Venzon DJ, Kulkarni V, Alicea C, Pilkington GR, Liyanage NP, Demberg T, Gordon SN, Wang Y, Hogg AE, Frey B, Patterson LJ, DiPasquale J, Montefiori DC, Sardesai NY, Reed SG, Berzofsky JA, Franchini G, Felber BK, Pavlakis GN, Robert-Guroff M. Vargas-Inchaustegui DA, et al. Among authors: alicea c. Clin Immunol. 2014 Aug;153(2):308-22. doi: 10.1016/j.clim.2014.05.008. Epub 2014 Jun 4. Clin Immunol. 2014. PMID: 24907411 Free PMC article.
DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge.
Rosati M, Bergamaschi C, Valentin A, Kulkarni V, Jalah R, Alicea C, Patel V, von Gegerfelt AS, Montefiori DC, Venzon DJ, Khan AS, Draghia-Akli R, Van Rompay KK, Felber BK, Pavlakis GN. Rosati M, et al. Among authors: alicea c. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15831-6. doi: 10.1073/pnas.0902628106. Epub 2009 Aug 28. Proc Natl Acad Sci U S A. 2009. PMID: 19717425 Free PMC article.
Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization.
Patel V, Valentin A, Kulkarni V, Rosati M, Bergamaschi C, Jalah R, Alicea C, Minang JT, Trivett MT, Ohlen C, Zhao J, Robert-Guroff M, Khan AS, Draghia-Akli R, Felber BK, Pavlakis GN. Patel V, et al. Among authors: alicea c. Vaccine. 2010 Jul 5;28(30):4827-36. doi: 10.1016/j.vaccine.2010.04.064. Epub 2010 May 6. Vaccine. 2010. PMID: 20451642 Free PMC article.
Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.
von Gegerfelt A, Valentin A, Alicea C, Van Rompay KK, Marthas ML, Montefiori DC, Pavlakis GN, Felber BK. von Gegerfelt A, et al. Among authors: alicea c. J Immunol. 2010 Sep 15;185(6):3348-58. doi: 10.4049/jimmunol.1000572. Epub 2010 Aug 11. J Immunol. 2010. PMID: 20702730 Free PMC article.
Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.
Kulkarni V, Jalah R, Ganneru B, Bergamaschi C, Alicea C, von Gegerfelt A, Patel V, Zhang GM, Chowdhury B, Broderick KE, Sardesai NY, Valentin A, Rosati M, Felber BK, Pavlakis GN. Kulkarni V, et al. Among authors: alicea c. Vaccine. 2011 Sep 9;29(39):6742-54. doi: 10.1016/j.vaccine.2010.12.056. Epub 2010 Dec 30. Vaccine. 2011. PMID: 21195080 Free PMC article.
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
Jalah R, Patel V, Kulkarni V, Rosati M, Alicea C, Ganneru B, von Gegerfelt A, Huang W, Guan Y, Broderick KE, Sardesai NY, LaBranche C, Montefiori DC, Pavlakis GN, Felber BK. Jalah R, et al. Among authors: alicea c. Hum Vaccin Immunother. 2012 Nov 1;8(11):1620-9. doi: 10.4161/hv.21407. Epub 2012 Aug 16. Hum Vaccin Immunother. 2012. PMID: 22894956 Free PMC article.
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.
Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, von Gegerfelt A, Huang W, Guan Y, Keele BF, Bess JW Jr, Piatak M Jr, Lifson JD, Williams WT, Shen X, Tomaras GD, Amara RR, Robinson HL, Johnson W, Broderick KE, Sardesai NY, Venzon DJ, Hirsch VM, Felber BK, Pavlakis GN. Patel V, et al. Among authors: alicea c. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2975-80. doi: 10.1073/pnas.1215393110. Epub 2013 Jan 28. Proc Natl Acad Sci U S A. 2013. PMID: 23359688 Free PMC article.
Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques.
Kulkarni V, Rosati M, Bear J, Pilkington GR, Jalah R, Bergamaschi C, Singh AK, Alicea C, Chowdhury B, Zhang GM, Kim EY, Wolinsky SM, Huang W, Guan Y, LaBranche C, Montefiori DC, Broderick KE, Sardesai NY, Valentin A, Felber BK, Pavlakis GN. Kulkarni V, et al. Among authors: alicea c. Hum Vaccin Immunother. 2013 Oct;9(10):2081-94. doi: 10.4161/hv.25473. Epub 2013 Jun 28. Hum Vaccin Immunother. 2013. PMID: 23811579 Free PMC article.
47 results