Lamming DW - Search Results

1

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.

Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM. Lamming DW, et al. Aging Cell. 2014 Oct;13(5):911-7. doi: 10.1111/acel.12256. Epub 2014 Jul 25. Aging Cell. 2014. PMID: 25059582 Free PMC article.

2

Dietary restriction of individual amino acids stimulates unique molecular responses in mouse liver.

Haws SA, Liu Y, Green CL, Babygirija R, Armstrong EA, Mehendale AT, Lamming DW, Denu JM. Haws SA, et al. Among authors: lamming dw. bioRxiv [Preprint]. 2023 Dec 7:2023.12.06.570456. doi: 10.1101/2023.12.06.570456. bioRxiv. 2023. PMID: 38106163 Free PMC article. Preprint.

3

A radical role for TOR in longevity.

Lamming DW, Sabatini DM. Lamming DW, et al. Cell Metab. 2011 Jun 8;13(6):617-8. doi: 10.1016/j.cmet.2011.05.006. Cell Metab. 2011. PMID: 21641542 Free PMC article.

4

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Lamming DW, et al. Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135. Science. 2012. PMID: 22461615 Free PMC article.

5

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. Robida-Stubbs S, et al. Among authors: lamming dw. Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007. Cell Metab. 2012. PMID: 22560223 Free PMC article.

6

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM. Yilmaz ÖH, et al. Among authors: lamming dw. Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163. Nature. 2012. PMID: 22722868 Free PMC article.

7

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA. Ye L, et al. Among authors: lamming dw. Front Genet. 2012 Sep 11;3:177. doi: 10.3389/fgene.2012.00177. eCollection 2012. Front Genet. 2012. PMID: 22973301 Free PMC article.

8

Rapalogs and mTOR inhibitors as anti-aging therapeutics.

Lamming DW, Ye L, Sabatini DM, Baur JA. Lamming DW, et al. J Clin Invest. 2013 Mar;123(3):980-9. doi: 10.1172/JCI64099. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454761 Free PMC article. Review.

9

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile.

Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L. Mercken EM, et al. Among authors: lamming dw. Aging Cell. 2013 Aug;12(4):645-51. doi: 10.1111/acel.12088. Epub 2013 Jun 5. Aging Cell. 2013. PMID: 23601134 Free PMC article.

10

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Lamming DW, et al. Aging Cell. 2013 Aug;12(4):712-8. doi: 10.1111/acel.12097. Epub 2013 Jun 7. Aging Cell. 2013. PMID: 23648089 Free PMC article.

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