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Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism.
Guttman-Yassky E, Ungar B, Noda S, Suprun M, Shroff A, Dutt R, Khattri S, Min M, Mansouri Y, Zheng X, Estrada YD, Singer GK, Suarez-Farinas M, Krueger JG, Lebwohl MG. Guttman-Yassky E, et al. Among authors: zheng x. J Allergy Clin Immunol. 2016 Jan;137(1):301-304. doi: 10.1016/j.jaci.2015.11.001. Epub 2015 Nov 20. J Allergy Clin Immunol. 2016. PMID: 26607705 No abstract available.
Residual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence.
Rozenblit M, Suarez-Farinas M, Shemer A, Khattri S, Gilleaudeau P, Sullivan-Whalen M, Zheng X, Xu H, Cardinale I, Krueger JG, Guttman-Yassky E. Rozenblit M, et al. Among authors: zheng x. J Allergy Clin Immunol. 2014 Oct;134(4):955-7. doi: 10.1016/j.jaci.2014.05.024. Epub 2014 Jul 2. J Allergy Clin Immunol. 2014. PMID: 24996261 Free PMC article. No abstract available.
Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin.
Correa da Rosa J, Malajian D, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Khattri S, Ungar B, Finney R, Xu H, Zheng X, Estrada YD, Peng X, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Correa da Rosa J, et al. Among authors: zheng x. J Allergy Clin Immunol. 2015 Mar;135(3):712-20. doi: 10.1016/j.jaci.2014.11.017. Epub 2015 Jan 10. J Allergy Clin Immunol. 2015. PMID: 25583101
RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications.
Suárez-Fariñas M, Ungar B, Correa da Rosa J, Ewald DA, Rozenblit M, Gonzalez J, Xu H, Zheng X, Peng X, Estrada YD, Dillon SR, Krueger JG, Guttman-Yassky E. Suárez-Fariñas M, et al. Among authors: zheng x. J Allergy Clin Immunol. 2015 May;135(5):1218-27. doi: 10.1016/j.jaci.2015.03.003. Epub 2015 Mar 31. J Allergy Clin Immunol. 2015. PMID: 25840722
Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing.
Suárez-Fariñas M, Ungar B, Noda S, Shroff A, Mansouri Y, Fuentes-Duculan J, Czernik A, Zheng X, Estrada YD, Xu H, Peng X, Shemer A, Krueger JG, Lebwohl MG, Guttman-Yassky E. Suárez-Fariñas M, et al. Among authors: zheng x. J Allergy Clin Immunol. 2015 Nov;136(5):1277-87. doi: 10.1016/j.jaci.2015.06.032. Epub 2015 Aug 24. J Allergy Clin Immunol. 2015. PMID: 26316095
Petrolatum: Barrier repair and antimicrobial responses underlying this "inert" moisturizer.
Czarnowicki T, Malajian D, Khattri S, Correa da Rosa J, Dutt R, Finney R, Dhingra N, Xiangyu P, Xu H, Estrada YD, Zheng X, Gilleaudeau P, Sullivan-Whalen M, Suaréz-Fariñas M, Shemer A, Krueger JG, Guttman-Yassky E. Czarnowicki T, et al. Among authors: zheng x. J Allergy Clin Immunol. 2016 Apr;137(4):1091-1102.e7. doi: 10.1016/j.jaci.2015.08.013. Epub 2015 Oct 1. J Allergy Clin Immunol. 2016. PMID: 26431582 Clinical Trial.
A mild topical steroid leads to progressive anti-inflammatory effects in the skin of patients with moderate-to-severe atopic dermatitis.
Brunner PM, Khattri S, Garcet S, Finney R, Oliva M, Dutt R, Fuentes-Duculan J, Zheng X, Li X, Bonifacio KM, Kunjravia N, Coats I, Cueto I, Gilleaudeau P, Sullivan-Whalen M, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Brunner PM, et al. Among authors: zheng x. J Allergy Clin Immunol. 2016 Jul;138(1):169-178. doi: 10.1016/j.jaci.2015.12.1323. Epub 2016 Mar 2. J Allergy Clin Immunol. 2016. PMID: 26948076
An IL-17-dominant immune profile is shared across the major orphan forms of ichthyosis.
Paller AS, Renert-Yuval Y, Suprun M, Esaki H, Oliva M, Huynh TN, Ungar B, Kunjravia N, Friedland R, Peng X, Zheng X, Estrada YD, Krueger JG, Choate KA, Suárez-Fariñas M, Guttman-Yassky E. Paller AS, et al. Among authors: zheng x. J Allergy Clin Immunol. 2017 Jan;139(1):152-165. doi: 10.1016/j.jaci.2016.07.019. Epub 2016 Aug 20. J Allergy Clin Immunol. 2017. PMID: 27554821 Free PMC article.
Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab.
Brunner PM, Pavel AB, Khattri S, Leonard A, Malik K, Rose S, Jim On S, Vekaria AS, Traidl-Hoffmann C, Singer GK, Baum D, Gilleaudeau P, Sullivan-Whalen M, Fuentes-Duculan J, Li X, Zheng X, Estrada Y, Garcet S, Wen HC, Gonzalez J, Coats I, Cueto I, Neumann AU, Lebwohl MG, Krueger JG, Guttman-Yassky E. Brunner PM, et al. Among authors: zheng x. J Allergy Clin Immunol. 2019 Jan;143(1):142-154. doi: 10.1016/j.jaci.2018.07.028. Epub 2018 Aug 17. J Allergy Clin Immunol. 2019. PMID: 30121291 Clinical Trial.
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