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VE-1902-A direct thrombin inhibitor with reversible covalent mechanism of action shows efficacy with reduced bleeding in rodent models of thrombosis.
Sivaraja M, Clemens DM, Sizikov S, Dash S, Xu C, Rienzo M, Yang B, Ryan M, Chattopadhyay M, Igoudin L, Chang SS, Keutzer S, Zalicki P, Estiarte MA, Shiau TP, Short KM, Williams DC, Datta A, Pozzi N, Di Cera E, Gibson CM, Fox KAA, Kita DB. Sivaraja M, et al. Among authors: shiau tp. Thromb Res. 2020 Jun;190:112-121. doi: 10.1016/j.thromres.2020.04.020. Epub 2020 Apr 19. Thromb Res. 2020. PMID: 32339947 Free PMC article.
Reversible covalent direct thrombin inhibitors.
Sivaraja M, Pozzi N, Rienzo M, Lin K, Shiau TP, Clemens DM, Igoudin L, Zalicki P, Chang SS, Estiarte MA, Short KM, Williams DC, Datta A, Di Cera E, Kita DB. Sivaraja M, et al. Among authors: shiau tp. PLoS One. 2018 Aug 2;13(8):e0201377. doi: 10.1371/journal.pone.0201377. eCollection 2018. PLoS One. 2018. PMID: 30071045 Free PMC article.
Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity.
Shiau TP, Low E, Kim B, Turtle ED, Francavilla C, O'Mahony DJ, Friedman L, D'Lima L, Jekle A, Debabov D, Zuck M, Alvarez NJ, Anderson M, Najafi RR, Jain RK. Shiau TP, et al. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5650-3. doi: 10.1016/j.bmcl.2013.08.027. Epub 2013 Aug 17. Bioorg Med Chem Lett. 2013. PMID: 23999044
NVC-422 inactivates Staphylococcus aureus toxins.
Jekle A, Yoon J, Zuck M, Najafi R, Wang L, Shiau T, Francavilla C, Rani SA, Eitzinger C, Nagl M, Anderson M, Debabov D. Jekle A, et al. Among authors: shiau t. Antimicrob Agents Chemother. 2013 Feb;57(2):924-9. doi: 10.1128/AAC.01945-12. Epub 2012 Dec 3. Antimicrob Agents Chemother. 2013. PMID: 23208720 Free PMC article.
Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines.
Low E, Kim B, Francavilla C, Shiau TP, Turtle ED, O'Mahony DJ, Alvarez N, Houchin A, Xu P, Zuck M, Celeri C, Anderson MB, Najafi RR, Jain RK. Low E, et al. Among authors: shiau tp. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3682-5. doi: 10.1016/j.bmcl.2011.04.084. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21570284
Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
Shiau TP, Turtle ED, Francavilla C, Alvarez NJ, Zuck M, Friedman L, O'Mahony DJ, Low E, Anderson MB, Najafi RR, Jain RK. Shiau TP, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3025-8. doi: 10.1016/j.bmcl.2011.03.036. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21470861
Novel N-chloroheterocyclic antimicrobials.
Francavilla C, Turtle ED, Kim B, O'Mahony DJ, Shiau TP, Low E, Alvarez NJ, Celeri CE, D'Lima L, Friedman LC, Ruado FS, Xu P, Zuck ME, Anderson MB, Najafi RR, Jain RK. Francavilla C, et al. Among authors: shiau tp. Bioorg Med Chem Lett. 2011 May 15;21(10):3029-33. doi: 10.1016/j.bmcl.2011.03.035. Epub 2011 Mar 16. Bioorg Med Chem Lett. 2011. PMID: 21459574
16 results