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IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.
Eslam M, McLeod D, Kelaeng KS, Mangia A, Berg T, Thabet K, Irving WL, Dore GJ, Sheridan D, Grønbæk H, Abate ML, Hartmann R, Bugianesi E, Spengler U, Rojas A, Booth DR, Weltman M, Mollison L, Cheng W, Riordan S, Mahajan H, Fischer J, Nattermann J, Douglas MW, Liddle C, Powell E, Romero-Gomez M, George J; International Liver Disease Genetics Consortium (ILDGC). Eslam M, et al. Among authors: hartmann r. Nat Genet. 2017 May;49(5):795-800. doi: 10.1038/ng.3836. Epub 2017 Apr 10. Nat Genet. 2017. PMID: 28394349 Free article.
Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes.
Terczyńska-Dyla E, Bibert S, Duong FH, Krol I, Jørgensen S, Collinet E, Kutalik Z, Aubert V, Cerny A, Kaiser L, Malinverni R, Mangia A, Moradpour D, Müllhaupt B, Negro F, Santoro R, Semela D, Semmo N; Swiss Hepatitis C Cohort Study Group; Heim MH, Bochud PY, Hartmann R. Terczyńska-Dyla E, et al. Among authors: hartmann r. Nat Commun. 2014 Dec 23;5:5699. doi: 10.1038/ncomms6699. Nat Commun. 2014. PMID: 25534433 Free article.
Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.
Ferraris P, Chandra PK, Panigrahi R, Aboulnasr F, Chava S, Kurt R, Pawlotsky JM, Wilkens L, Osterlund P, Hartmann R, Balart LA, Wu T, Dash S. Ferraris P, et al. Among authors: hartmann r. Am J Pathol. 2016 Apr;186(4):938-51. doi: 10.1016/j.ajpath.2015.11.027. Epub 2016 Feb 16. Am J Pathol. 2016. PMID: 26896692 Free PMC article.
The role of IFN in the development of NAFLD and NASH.
Møhlenberg M, Terczynska-Dyla E, Thomsen KL, George J, Eslam M, Grønbæk H, Hartmann R. Møhlenberg M, et al. Among authors: hartmann r. Cytokine. 2019 Dec;124:154519. doi: 10.1016/j.cyto.2018.08.013. Epub 2018 Aug 21. Cytokine. 2019. PMID: 30139548 Review.
Interferon lambda 4 genotype and pathway in alcoholic hepatitis.
Støy S, Terczynska-Dyla E, Veidal SS, Rigbolt K, Vilstrup H, Grønbaek H, Hartmann R, Sandahl TD. Støy S, et al. Among authors: hartmann r. Scand J Gastroenterol. 2021 Mar;56(3):304-311. doi: 10.1080/00365521.2021.1874046. Epub 2021 Feb 19. Scand J Gastroenterol. 2021. PMID: 33602032
1,246 results