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Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
Bioorg Med Chem. 2017 Oct 1;25(19):5114-5127. doi: 10.1016/j.bmc.2017.04.005. Epub 2017 Apr 9.
Bioorg Med Chem. 2017.
PMID: 28434781
Free PMC article.
Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.
Chang YC, Yu X, Zhang Y, Tie Y, Wang YF, Yashchuk S, Ghosh AK, Harrison RW, Weber IT.
Chang YC, et al. Among authors: yashchuk s.
J Med Chem. 2012 Apr 12;55(7):3387-97. doi: 10.1021/jm300072d. Epub 2012 Mar 22.
J Med Chem. 2012.
PMID: 22401672
Free PMC article.
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GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration.
Salcedo Gómez PM, Amano M, Yashchuk S, Mizuno A, Das D, Ghosh AK, Mitsuya H.
Salcedo Gómez PM, et al. Among authors: yashchuk s.
Antimicrob Agents Chemother. 2013 Dec;57(12):6110-21. doi: 10.1128/AAC.01420-13. Epub 2013 Sep 30.
Antimicrob Agents Chemother. 2013.
PMID: 24080647
Free PMC article.
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Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation.
Ghosh AK, Yashchuk S, Mizuno A, Chakraborty N, Agniswamy J, Wang YF, Aoki M, Gomez PM, Amano M, Weber IT, Mitsuya H.
Ghosh AK, et al. Among authors: yashchuk s.
ChemMedChem. 2015 Jan;10(1):107-15. doi: 10.1002/cmdc.201402358. Epub 2014 Oct 21.
ChemMedChem. 2015.
PMID: 25336073
Free PMC article.
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Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.
Agniswamy J, Louis JM, Shen CH, Yashchuk S, Ghosh AK, Weber IT.
Agniswamy J, et al. Among authors: yashchuk s.
J Med Chem. 2015 Jun 25;58(12):5088-95. doi: 10.1021/acs.jmedchem.5b00474. Epub 2015 Jun 4.
J Med Chem. 2015.
PMID: 26010498
Free PMC article.
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Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.
Ghosh AK, Takayama J, Kassekert LA, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.
Ghosh AK, et al. Among authors: yashchuk s.
Bioorg Med Chem Lett. 2015 Nov 1;25(21):4903-4909. doi: 10.1016/j.bmcl.2015.05.052. Epub 2015 May 30.
Bioorg Med Chem Lett. 2015.
PMID: 26096678
Free PMC article.
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Effect of Graphene Oxide Addition on the Anticorrosion Properties of the Phosphate Coatings in Neutral and Acidic Aqueous Media.
Bautin VA, Bardin IV, Kvaratskheliya AR, Yashchuk SV, Hristoforou EV.
Bautin VA, et al. Among authors: yashchuk sv.
Materials (Basel). 2022 Sep 22;15(19):6588. doi: 10.3390/ma15196588.
Materials (Basel). 2022.
PMID: 36233928
Free PMC article.
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