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Page 1
Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
Hübner MP, Ehrens A, Koschel M, Dubben B, Lenz F, Frohberger SJ, Specht S, Quirynen L, Lachau-Durand S, Tekle F, Baeten B, Engelen M, Mackenzie CD, Hoerauf A. Hübner MP, et al. Among authors: quirynen l. PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006320. doi: 10.1371/journal.pntd.0006320. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30650105 Free PMC article.
Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.
Fischer C, Ibiricu Urriza I, Bulman CA, Lim KC, Gut J, Lachau-Durand S, Engelen M, Quirynen L, Tekle F, Baeten B, Beerntsen B, Lustigman S, Sakanari J. Fischer C, et al. Among authors: quirynen l. PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006787. doi: 10.1371/journal.pntd.0006787. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30650084 Free PMC article.
Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.
Sjoberg HT, Pionnier N, Aljayyoussi G, Metuge HM, Njouendou AJ, Chunda VC, Fombad FF, Tayong DB, Gandjui NVT, Akumtoh DN, Chounna PWN, Ndzeshang BL, Lachaud S, Tekle F, Quirynen L, Engelen M, Baeten B, Steven A, Ward SA, Taylor MJ, Wanji S, Turner JD. Sjoberg HT, et al. Among authors: quirynen l. PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006356. doi: 10.1371/journal.pntd.0006356. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30650071 Free PMC article.
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
McGowan D, Nyanguile O, Cummings MD, Vendeville S, Vandyck K, Van den Broeck W, Boutton CW, De Bondt H, Quirynen L, Amssoms K, Bonfanti JF, Last S, Rombauts K, Tahri A, Hu L, Delouvroy F, Vermeiren K, Vandercruyssen G, Van der Helm L, Cleiren E, Mostmans W, Lory P, Pille G, Van Emelen K, Fanning G, Pauwels F, Lin TI, Simmen K, Raboisson P. McGowan D, et al. Among authors: quirynen l. Bioorg Med Chem Lett. 2009 May 1;19(9):2492-6. doi: 10.1016/j.bmcl.2009.03.035. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19342234
1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
Nyanguile O, Pauwels F, Van den Broeck W, Boutton CW, Quirynen L, Ivens T, van der Helm L, Vandercruyssen G, Mostmans W, Delouvroy F, Dehertogh P, Cummings MD, Bonfanti JF, Simmen KA, Raboisson P. Nyanguile O, et al. Among authors: quirynen l. Antimicrob Agents Chemother. 2008 Dec;52(12):4420-31. doi: 10.1128/AAC.00669-08. Epub 2008 Oct 13. Antimicrob Agents Chemother. 2008. PMID: 18852280 Free PMC article.
The antiplasmodial activity of isolates from Ajuga remota.
Kuria KA, Chepkwony H, Govaerts C, Roets E, Busson R, De Witte P, Zupko I, Hoornaert G, Quirynen L, Maes L, Janssens L, Hoogmartens J, Laekeman G. Kuria KA, et al. Among authors: quirynen l. J Nat Prod. 2002 May;65(5):789-93. doi: 10.1021/np0104626. J Nat Prod. 2002. PMID: 12027771