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The human T-cell leukemia virus type-1 p30II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis.
Romeo M, Hutchison T, Malu A, White A, Kim J, Gardner R, Smith K, Nelson K, Bergeson R, McKee R, Harrod C, Ratner L, Lüscher B, Martinez E, Harrod R. Romeo M, et al. Among authors: kim j. Virology. 2018 May;518:103-115. doi: 10.1016/j.virol.2018.02.010. Epub 2018 Feb 20. Virology. 2018. PMID: 29462755 Free PMC article.
Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30(II) accessory protein and the induction of oncogenic cellular transformation by p30(II)/c-MYC.
Romeo MM, Ko B, Kim J, Brady R, Heatley HC, He J, Harrod CK, Barnett B, Ratner L, Lairmore MD, Martinez E, Lüscher B, Robson CN, Henriksson M, Harrod R. Romeo MM, et al. Among authors: kim j. Virology. 2015 Feb;476:271-288. doi: 10.1016/j.virol.2014.12.008. Epub 2015 Jan 5. Virology. 2015. PMID: 25569455 Free PMC article.
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