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Gi- and Gs-coupled GPCRs show different modes of G-protein binding.
Van Eps N, Altenbach C, Caro LN, Latorraca NR, Hollingsworth SA, Dror RO, Ernst OP, Hubbell WL. Van Eps N, et al. Among authors: hollingsworth sa. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2383-2388. doi: 10.1073/pnas.1721896115. Epub 2018 Feb 20. Proc Natl Acad Sci U S A. 2018. PMID: 29463720 Free PMC article.
Molecular mechanism of GPCR-mediated arrestin activation.
Latorraca NR, Wang JK, Bauer B, Townshend RJL, Hollingsworth SA, Olivieri JE, Xu HE, Sommer ME, Dror RO. Latorraca NR, et al. Among authors: hollingsworth sa. Nature. 2018 May;557(7705):452-456. doi: 10.1038/s41586-018-0077-3. Epub 2018 May 2. Nature. 2018. PMID: 29720655 Free PMC article.
Molecular Dynamics Simulation for All.
Hollingsworth SA, Dror RO. Hollingsworth SA, et al. Neuron. 2018 Sep 19;99(6):1129-1143. doi: 10.1016/j.neuron.2018.08.011. Neuron. 2018. PMID: 30236283 Free PMC article. Review.
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G. Krishna Kumar K, et al. Among authors: hollingsworth sa. Cell. 2019 Jan 24;176(3):448-458.e12. doi: 10.1016/j.cell.2018.11.040. Epub 2019 Jan 10. Cell. 2019. PMID: 30639101 Free PMC article.
Structure and mechanism of the cation-chloride cotransporter NKCC1.
Chew TA, Orlando BJ, Zhang J, Latorraca NR, Wang A, Hollingsworth SA, Chen DH, Dror RO, Liao M, Feng L. Chew TA, et al. Among authors: hollingsworth sa. Nature. 2019 Aug;572(7770):488-492. doi: 10.1038/s41586-019-1438-2. Epub 2019 Jul 31. Nature. 2019. PMID: 31367042 Free PMC article.
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.
Latorraca NR, Masureel M, Hollingsworth SA, Heydenreich FM, Suomivuori CM, Brinton C, Townshend RJL, Bouvier M, Kobilka BK, Dror RO. Latorraca NR, et al. Among authors: hollingsworth sa. Cell. 2020 Dec 23;183(7):1813-1825.e18. doi: 10.1016/j.cell.2020.11.014. Epub 2020 Dec 8. Cell. 2020. PMID: 33296703 Free PMC article.
36 results