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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR. Cobo-Vuilleumier N, et al. Among authors: baquie m. Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0. Nat Commun. 2018. PMID: 29662071 Free PMC article.
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis.
Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR. Baquié M, et al. Hum Mol Genet. 2018 Jan 15;27(2):406. doi: 10.1093/hmg/ddx402. Hum Mol Genet. 2018. PMID: 29186426 Free article. No abstract available.
Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB. Kirkpatrick CL, et al. Among authors: baquie m. J Biol Chem. 2011 Sep 16;286(37):32300-12. doi: 10.1074/jbc.M111.247866. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784843 Free PMC article.
Pancreatic insulin content regulation by the estrogen receptor ER alpha.
Alonso-Magdalena P, Ropero AB, Carrera MP, Cederroth CR, Baquié M, Gauthier BR, Nef S, Stefani E, Nadal A. Alonso-Magdalena P, et al. Among authors: baquie m. PLoS One. 2008 Apr 30;3(4):e2069. doi: 10.1371/journal.pone.0002069. PLoS One. 2008. PMID: 18446233 Free PMC article.
Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.
Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH. Bonner C, et al. Among authors: baquie m. J Biol Chem. 2011 Jul 22;286(29):25719-28. doi: 10.1074/jbc.M110.215525. Epub 2011 May 31. J Biol Chem. 2011. PMID: 21628466 Free PMC article.
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach.
Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn L, Bremer S, van Thriel C, Krause KH, Hengstler JG, Rahnenführer J, Leist M, Sachinidis A. Krug AK, et al. Among authors: baquie m. Arch Toxicol. 2013 Jan;87(1):123-43. doi: 10.1007/s00204-012-0967-3. Epub 2012 Nov 21. Arch Toxicol. 2013. PMID: 23179753 Free PMC article.
19 results