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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR. Cobo-Vuilleumier N, et al. Among authors: gauthier br. Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0. Nat Commun. 2018. PMID: 29662071 Free PMC article.
Pancreatic insulin content regulation by the estrogen receptor ER alpha.
Alonso-Magdalena P, Ropero AB, Carrera MP, Cederroth CR, Baquié M, Gauthier BR, Nef S, Stefani E, Nadal A. Alonso-Magdalena P, et al. Among authors: gauthier br. PLoS One. 2008 Apr 30;3(4):e2069. doi: 10.1371/journal.pone.0002069. PLoS One. 2008. PMID: 18446233 Free PMC article.
Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.
Serre-Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, Gauthier BR, Diaferia GR, Giepmans BN, Lupi R, Marchetti P, Deng S, Buhler L, Berney T, Cirulli V, Meda P. Serre-Beinier V, et al. Among authors: gauthier br. Hum Mol Genet. 2009 Feb 1;18(3):428-39. doi: 10.1093/hmg/ddn370. Epub 2008 Nov 10. Hum Mol Genet. 2009. PMID: 19000992 Free PMC article.
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis.
Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR. Baquié M, et al. Among authors: gauthier br. Hum Mol Genet. 2011 Jul 15;20(14):2823-33. doi: 10.1093/hmg/ddr193. Epub 2011 May 2. Hum Mol Genet. 2011. PMID: 21536586
86 results