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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR. Cobo-Vuilleumier N, et al. Among authors: schoonjans k. Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0. Nat Commun. 2018. PMID: 29662071 Free PMC article.
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.
Cobo I, Martinelli P, Flández M, Bakiri L, Zhang M, Carrillo-de-Santa-Pau E, Jia J, Sánchez-Arévalo Lobo VJ, Megías D, Felipe I, Del Pozo N, Millán I, Thommesen L, Bruland T, Olson SH, Smith J, Schoonjans K, Bamlet WR, Petersen GM, Malats N, Amundadottir LT, Wagner EF, Real FX. Cobo I, et al. Among authors: schoonjans k. Nature. 2018 Feb 22;554(7693):533-537. doi: 10.1038/nature25751. Epub 2018 Feb 14. Nature. 2018. PMID: 29443959 Free PMC article.
Liver receptor homolog-1 is essential for pregnancy.
Zhang C, Large MJ, Duggavathi R, DeMayo FJ, Lydon JP, Schoonjans K, Kovanci E, Murphy BD. Zhang C, et al. Among authors: schoonjans k. Nat Med. 2013 Aug;19(8):1061-6. doi: 10.1038/nm.3192. Epub 2013 Jun 30. Nat Med. 2013. PMID: 23817023 Free PMC article.
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Fang S, et al. Among authors: schoonjans k. Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5. Nat Med. 2015. PMID: 25559344 Free PMC article.
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.
Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, Spinelli V, Hennuyer N, Caron S, Bantubungi K, Caiazzo R, Reimann F, Marchetti P, Lefebvre P, Bäckhed F, Gribble FM, Schoonjans K, Pattou F, Tailleux A, Staels B, Lestavel S. Trabelsi MS, et al. Among authors: schoonjans k. Nat Commun. 2015 Jul 2;6:7629. doi: 10.1038/ncomms8629. Nat Commun. 2015. PMID: 26134028 Free PMC article.
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J. Katsyuba E, et al. Among authors: schoonjans k. Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356218 Free PMC article.
195 results