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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, Martin OR, Millan MJ. Boland B, et al. Among authors: bezard e. Nat Rev Drug Discov. 2018 Sep;17(9):660-688. doi: 10.1038/nrd.2018.109. Epub 2018 Aug 17. Nat Rev Drug Discov. 2018. PMID: 30116051 Free PMC article. Review.
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Laferrière F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock EM, Wagner U, Afroz T, Boersema PJ, Barmettler G, Foti SC, Asi YT, Isaacs AM, Al-Amoudi A, Lewis A, Stahlberg H, Ravits J, De Giorgi F, Ichas F, Bezard E, Picotti P, Lashley T, Polymenidou M. Laferrière F, et al. Among authors: bezard e. Nat Neurosci. 2019 Jan;22(1):65-77. doi: 10.1038/s41593-018-0294-y. Epub 2018 Dec 17. Nat Neurosci. 2019. PMID: 30559480
Novel pharmacological targets for the treatment of Parkinson's disease.
Schapira AH, Bezard E, Brotchie J, Calon F, Collingridge GL, Ferger B, Hengerer B, Hirsch E, Jenner P, Le Novère N, Obeso JA, Schwarzschild MA, Spampinato U, Davidai G. Schapira AH, et al. Among authors: bezard e. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. doi: 10.1038/nrd2087. Nat Rev Drug Discov. 2006. PMID: 17016425 Review.
L-DOPA impairs proteasome activity in parkinsonism through D1 dopamine receptor.
Berthet A, Bezard E, Porras G, Fasano S, Barroso-Chinea P, Dehay B, Martinez A, Thiolat ML, Nosten-Bertrand M, Giros B, Baufreton J, Li Q, Bloch B, Martin-Negrier ML. Berthet A, et al. Among authors: bezard e. J Neurosci. 2012 Jan 11;32(2):681-91. doi: 10.1523/JNEUROSCI.1541-11.2012. J Neurosci. 2012. PMID: 22238104 Free PMC article.
347 results