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Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function.
Scoville SD, Nalin AP, Chen L, Chen L, Zhang MH, McConnell K, Beceiro Casas S, Ernst G, Traboulsi AA, Hashi N, Williams M, Zhang X, Hughes T, Mishra A, Benson DM, Saultz JN, Yu J, Freud AG, Caligiuri MA, Mundy-Bosse BL. Scoville SD, et al. Blood. 2018 Oct 25;132(17):1792-1804. doi: 10.1182/blood-2018-03-838474. Epub 2018 Aug 29. Blood. 2018. PMID: 30158248 Free PMC article.
Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease.
Bernot KM, Nemer JS, Santhanam R, Liu S, Zorko NA, Whitman SP, Dickerson KE, Zhang M, Yang X, McConnell KK, Ahmed EH, Muñoz MR, Siebenaler RF, Marcucci GG, Mundy-Bosse BL, Brook DL, Garman S, Dorrance AM, Zhang X, Zhang J, Lee RJ, Blum W, Caligiuri MA, Marcucci G. Bernot KM, et al. Blood. 2013 Nov 28;122(23):3778-83. doi: 10.1182/blood-2013-06-507426. Epub 2013 Oct 1. Blood. 2013. PMID: 24085765 Free PMC article.
The natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling.
Deng Y, Chu J, Ren Y, Fan Z, Ji X, Mundy-Bosse B, Yuan S, Hughes T, Zhang J, Cheema B, Camardo AT, Xia Y, Wu LC, Wang LS, He X, Kinghorn AD, Li X, Caligiuri MA, Yu J. Deng Y, et al. J Immunol. 2014 Sep 15;193(6):2994-3002. doi: 10.4049/jimmunol.1302600. Epub 2014 Aug 13. J Immunol. 2014. PMID: 25122922 Free PMC article.
PTEN is a negative regulator of NK cell cytolytic function.
Briercheck EL, Trotta R, Chen L, Hartlage AS, Cole JP, Cole TD, Mao C, Banerjee PP, Hsu HT, Mace EM, Ciarlariello D, Mundy-Bosse BL, Garcia-Cao I, Scoville SD, Yu L, Pilarski R, Carson WE 3rd, Leone G, Pandolfi PP, Yu J, Orange JS, Caligiuri MA. Briercheck EL, et al. J Immunol. 2015 Feb 15;194(4):1832-40. doi: 10.4049/jimmunol.1401224. Epub 2015 Jan 16. J Immunol. 2015. PMID: 25595786 Free PMC article.
The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells.
Martin del Campo SE, Levine KM, Mundy-Bosse BL, Grignol VP, Fairchild ET, Campbell AR, Trikha P, Mace TA, Paul BK, Jaime-Ramirez AC, Markowitz J, Kondadasula SV, Guenterberg KD, McClory S, Karpa VI, Pan X, Olencki TE, Monk JP, Mortazavi A, Tridandapani S, Lesinski GB, Byrd JC, Caligiuri MA, Shah MH, Carson WE 3rd. Martin del Campo SE, et al. J Immunol. 2015 Sep 1;195(5):1995-2005. doi: 10.4049/jimmunol.1400084. Epub 2015 Aug 3. J Immunol. 2015. PMID: 26238487 Free PMC article.
NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines.
Jaime-Ramirez AC, McMichael E, Kondadasula S, Skinner CC, Mundy-Bosse BL, Luedke E, Jones NB, Mani A, Roda J, Karpa V, Li H, Li J, Elavazhagan S, La Perle KM, Schmitt AC, Lu Y, Zhang X, Pan X, Mao H, Davis M, Jarjoura D, Butchar JP, Poi M, Phelps M, Tridandapani S, Byrd JC, Caligiuri MA, Lee RJ, Carson WE 3rd. Jaime-Ramirez AC, et al. Cancer Immunol Res. 2016 Apr;4(4):323-336. doi: 10.1158/2326-6066.CIR-15-0168. Epub 2016 Feb 10. Cancer Immunol Res. 2016. PMID: 26865456 Free PMC article.
NKp80 Defines a Critical Step during Human Natural Killer Cell Development.
Freud AG, Keller KA, Scoville SD, Mundy-Bosse BL, Cheng S, Youssef Y, Hughes T, Zhang X, Mo X, Porcu P, Baiocchi RA, Yu J, Carson WE 3rd, Caligiuri MA. Freud AG, et al. Cell Rep. 2016 Jul 12;16(2):379-391. doi: 10.1016/j.celrep.2016.05.095. Epub 2016 Jun 30. Cell Rep. 2016. PMID: 27373165 Free PMC article.
43 results