Yan Y - Search Results

1

Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).

Gu X, Bridges MD, Yan Y, de Waal PW, Zhou XE, Suino-Powell KM, Xu HE, Hubbell WL, Melcher K. Gu X, et al. Among authors: yan y. J Biol Chem. 2018 Nov 2;293(44):16994-17007. doi: 10.1074/jbc.RA118.004101. Epub 2018 Sep 11. J Biol Chem. 2018. PMID: 30206123 Free PMC article.

2

A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK).

Yan Y, Gu X, Xu HE, Melcher K. Yan Y, et al. Methods Protoc. 2018 Mar;1(1):3. doi: 10.3390/mps1010003. Epub 2017 Oct 13. Methods Protoc. 2018. PMID: 29451563 Free PMC article.

3

Structure and Physiological Regulation of AMPK.

Yan Y, Zhou XE, Xu HE, Melcher K. Yan Y, et al. Int J Mol Sci. 2018 Nov 9;19(11):3534. doi: 10.3390/ijms19113534. Int J Mol Sci. 2018. PMID: 30423971 Free PMC article. Review.

4

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.

Yan Y, Zhou XE, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K. Yan Y, et al. J Biol Chem. 2019 Jan 18;294(3):953-967. doi: 10.1074/jbc.RA118.004883. Epub 2018 Nov 26. J Biol Chem. 2019. PMID: 30478170 Free PMC article.

5

Structure of an AMPK complex in an inactive, ATP-bound state.

Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, Miller LJ, Xu HE, Griffin PR, Kossiakoff AA, Melcher K. Yan Y, et al. Science. 2021 Jul 23;373(6553):413-419. doi: 10.1126/science.abe7565. Science. 2021. PMID: 34437114 Free PMC article.

6

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing.

Gu X, Yan Y, Novick SJ, Kovach A, Goswami D, Ke J, Tan MHE, Wang L, Li X, de Waal PW, Webb MR, Griffin PR, Xu HE, Melcher K. Gu X, et al. Among authors: yan y. J Biol Chem. 2017 Jul 28;292(30):12653-12666. doi: 10.1074/jbc.M117.793018. Epub 2017 Jun 14. J Biol Chem. 2017. PMID: 28615457 Free PMC article.

7

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites.

Yan Y, Xu TH, Harikumar KG, Miller LJ, Melcher K, Xu HE. Yan Y, et al. J Biol Chem. 2017 Sep 22;292(38):15826-15837. doi: 10.1074/jbc.M117.789669. Epub 2017 Aug 8. J Biol Chem. 2017. PMID: 28790170 Free PMC article.

8

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.

Pinkosky SL, Scott JW, Desjardins EM, Smith BK, Day EA, Ford RJ, Langendorf CG, Ling NXY, Nero TL, Loh K, Galic S, Hoque A, Smiles WJ, Ngoei KRW, Parker MW, Yan Y, Melcher K, Kemp BE, Oakhill JS, Steinberg GR. Pinkosky SL, et al. Among authors: yan y. Nat Metab. 2020 Sep;2(9):873-881. doi: 10.1038/s42255-020-0245-2. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719536 Free PMC article.

9

Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio.

Xu TH, Yan Y, Kang Y, Jiang Y, Melcher K, Xu HE. Xu TH, et al. Among authors: yan y. Cell Discov. 2016 Aug 23;2:16026. doi: 10.1038/celldisc.2016.26. eCollection 2016. Cell Discov. 2016. PMID: 27625790 Free PMC article.

10

Defining the minimum substrate and charge recognition model of gamma-secretase.

Yan Y, Xu TH, Melcher K, Xu HE. Yan Y, et al. Acta Pharmacol Sin. 2017 Oct;38(10):1412-1424. doi: 10.1038/aps.2017.35. Epub 2017 Apr 17. Acta Pharmacol Sin. 2017. PMID: 28414207 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

18,056 results

Search Page