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Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.
Ghosh AK, Jadhav RD, Simpson H, Kovela S, Osswald H, Agniswamy J, Wang YF, Hattori SI, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: jadhav rd. Eur J Med Chem. 2018 Dec 5;160:171-182. doi: 10.1016/j.ejmech.2018.09.046. Epub 2018 Sep 18. Eur J Med Chem. 2018. PMID: 30340140 Free PMC article.
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.
Jadhav RD, Kadam KS, Kandre S, Guha T, Reddy MM, Brahma MK, Deshmukh NJ, Dixit A, Doshi L, Potdar N, Enose AA, Vishwakarma RA, Sivaramakrishnan H, Srinivasan S, Nemmani KV, Gupte A, Gangopadhyay AK, Sharma R. Jadhav RD, et al. Eur J Med Chem. 2012 Aug;54:324-42. doi: 10.1016/j.ejmech.2012.05.016. Epub 2012 May 22. Eur J Med Chem. 2012. PMID: 22683241
Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.
Motiwala H, Kandre S, Birar V, Kadam KS, Rodge A, Jadhav RD, Mahesh Kumar Reddy M, Brahma MK, Deshmukh NJ, Dixit A, Doshi L, Gupte A, Gangopadhyay AK, Vishwakarma RA, Srinivasan S, Sharma M, Nemmani KV, Sharma R. Motiwala H, et al. Among authors: jadhav rd. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5812-7. doi: 10.1016/j.bmcl.2011.07.109. Epub 2011 Aug 4. Bioorg Med Chem Lett. 2011. PMID: 21868220
A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Inoyama D, Awasthi D, Capodagli GC, Tsotetsi K, Sukheja P, Zimmerman M, Li SG, Jadhav R, Russo R, Wang X, Grady C, Richmann T, Shrestha R, Li L, Ahn YM, Ho Liang HP, Mina M, Park S, Perlin DS, Connell N, Dartois V, Alland D, Neiditch MB, Kumar P, Freundlich JS. Inoyama D, et al. Cell Chem Biol. 2020 May 21;27(5):560-570.e10. doi: 10.1016/j.chembiol.2020.02.007. Epub 2020 Mar 19. Cell Chem Biol. 2020. PMID: 32197094 Free PMC article.
Antitubercular Triazines: Optimization and Intrabacterial Metabolism.
Wang X, Inoyama D, Russo R, Li SG, Jadhav R, Stratton TP, Mittal N, Bilotta JA, Singleton E, Kim T, Paget SD, Pottorf RS, Ahn YM, Davila-Pagan A, Kandasamy S, Grady C, Hussain S, Soteropoulos P, Zimmerman MD, Ho HP, Park S, Dartois V, Ekins S, Connell N, Kumar P, Freundlich JS. Wang X, et al. Cell Chem Biol. 2020 Feb 20;27(2):172-185.e11. doi: 10.1016/j.chembiol.2019.10.010. Epub 2019 Nov 8. Cell Chem Biol. 2020. PMID: 31711854 Free PMC article.