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Abemaciclib in combination with endocrine therapy for East Asian patients with HR+, HER2- advanced breast cancer: MONARCH 2 & 3 trials.
Toi M, Inoue K, Masuda N, Iwata H, Sohn J, Hae Park I, Im SA, Chen SC, Enatsu S, Turner PK, André VAM, Hardebeck MC, Sakaguchi S, Goetz MP, Sledge GW Jr. Toi M, et al. Among authors: hardebeck mc. Cancer Sci. 2021 Jun;112(6):2381-2392. doi: 10.1111/cas.14877. Epub 2021 May 1. Cancer Sci. 2021. PMID: 33686753 Free PMC article. Clinical Trial.
nextMONARCH: Abemaciclib Monotherapy or Combined With Tamoxifen for Metastatic Breast Cancer.
Hamilton E, Cortes J, Ozyilkan O, Chen SC, Petrakova K, Manikhas A, Jerusalem G, Hegg R, Huober J, Chapman SC, Lu Y, Hardebeck MC, Bear MM, Johnston EL, Martin M. Hamilton E, et al. Among authors: hardebeck mc. Clin Breast Cancer. 2021 Jun;21(3):181-190.e2. doi: 10.1016/j.clbc.2020.09.011. Epub 2020 Sep 30. Clin Breast Cancer. 2021. PMID: 33148479 Clinical Trial.
Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma.
Gil del Alcazar CR, Hardebeck MC, Mukherjee B, Tomimatsu N, Gao X, Yan J, Xie XJ, Bachoo R, Li L, Habib AA, Burma S. Gil del Alcazar CR, et al. Among authors: hardebeck mc. Clin Cancer Res. 2014 Mar 1;20(5):1235-48. doi: 10.1158/1078-0432.CCR-13-1607. Epub 2013 Dec 23. Clin Cancer Res. 2014. PMID: 24366691 Free PMC article.
DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification.
Camacho CV, Todorova PK, Hardebeck MC, Tomimatsu N, Gil del Alcazar CR, Ilcheva M, Mukherjee B, McEllin B, Vemireddy V, Hatanpaa K, Story MD, Habib AA, Murty VV, Bachoo R, Burma S. Camacho CV, et al. Among authors: hardebeck mc. Oncogene. 2015 Feb 19;34(8):1064-72. doi: 10.1038/onc.2014.29. Epub 2014 Mar 17. Oncogene. 2015. PMID: 24632607 Free PMC article.