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Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.
Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE. Wienert B, et al. Among authors: corn je. Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18. Science. 2019. PMID: 31000663 Free PMC article.
Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Baltimore D, et al. Among authors: corn je. Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. Science. 2015. PMID: 25791083 Free PMC article.
Cornerstones of CRISPR-Cas in drug discovery and therapy.
Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE. Fellmann C, et al. Among authors: corn je. Nat Rev Drug Discov. 2017 Feb;16(2):89-100. doi: 10.1038/nrd.2016.238. Epub 2016 Dec 23. Nat Rev Drug Discov. 2017. PMID: 28008168 Free PMC article. Review.
Genome editing via delivery of Cas9 ribonucleoprotein.
DeWitt MA, Corn JE, Carroll D. DeWitt MA, et al. Among authors: corn je. Methods. 2017 May 15;121-122:9-15. doi: 10.1016/j.ymeth.2017.04.003. Epub 2017 Apr 12. Methods. 2017. PMID: 28410976 Free PMC article.
Disabling Cas9 by an anti-CRISPR DNA mimic.
Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Shin J, et al. Among authors: corn je. Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul. Sci Adv. 2017. PMID: 28706995 Free PMC article.
Discovery of stimulation-responsive immune enhancers with CRISPR activation.
Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Simeonov DR, et al. Among authors: corn je. Nature. 2017 Sep 7;549(7670):111-115. doi: 10.1038/nature23875. Epub 2017 Aug 30. Nature. 2017. PMID: 28854172 Free PMC article.
90 results