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A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.
Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. Fernandez IZ, et al. Among authors: gumbart jc. J Exp Med. 2019 Jun 3;216(6):1255-1267. doi: 10.1084/jem.20182015. Epub 2019 Apr 30. J Exp Med. 2019. PMID: 31040184 Free PMC article.
Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.
Bhattarai P, Hegde P, Li W, Prathipati PK, Stevens CM, Yang L, Zhou H, Pandya A, Cunningham K, Grissom J, Roman Sotelo M, Sowards M, Calisto L, Destache CJ, Rocha-Sanchez S, Gumbart JC, Zgurskaya HI, Jackson M, North EJ. Bhattarai P, et al. Among authors: gumbart jc. J Med Chem. 2023 Jan 12;66(1):170-187. doi: 10.1021/acs.jmedchem.2c00352. Epub 2022 Dec 23. J Med Chem. 2023. PMID: 36563291 Free PMC article.
Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein.
Russell Lewis B, Uddin MR, Moniruzzaman M, Kuo KM, Higgins AJ, Shah LMN, Sobott F, Parks JM, Hammerschmid D, Gumbart JC, Zgurskaya HI, Reading E. Russell Lewis B, et al. Among authors: gumbart jc. Nat Commun. 2023 Jul 18;14(1):3900. doi: 10.1038/s41467-023-39615-x. Nat Commun. 2023. PMID: 37463890 Free PMC article.
Living on the edge: Simulations of bacterial outer-membrane proteins.
Pavlova A, Hwang H, Lundquist K, Balusek C, Gumbart JC. Pavlova A, et al. Among authors: gumbart jc. Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1753-9. doi: 10.1016/j.bbamem.2016.01.020. Epub 2016 Jan 28. Biochim Biophys Acta. 2016. PMID: 26826270 Free article. Review.
C-terminal kink formation is required for lateral gating in BamA.
Lundquist K, Bakelar J, Noinaj N, Gumbart JC. Lundquist K, et al. Among authors: gumbart jc. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7942-E7949. doi: 10.1073/pnas.1722530115. Epub 2018 Aug 7. Proc Natl Acad Sci U S A. 2018. PMID: 30087180 Free PMC article.
Correction: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.
Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. Fernandez IZ, et al. Among authors: gumbart jc. J Exp Med. 2019 Jun 3;216(6):1465. doi: 10.1084/jem.2018201505102019c. Epub 2019 May 14. J Exp Med. 2019. PMID: 31088899 Free PMC article. No abstract available.
151 results