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Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.
Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L. Walston J, et al. Among authors: de cabo r. J Am Geriatr Soc. 2019 Aug;67(8):1559-1564. doi: 10.1111/jgs.15928. Epub 2019 May 2. J Am Geriatr Soc. 2019. PMID: 31045254 Free PMC article.
Kynurenines link chronic inflammation to functional decline and physical frailty.
Westbrook R, Chung T, Lovett J, Ward C, Joca H, Yang H, Khadeer M, Tian J, Xue QL, Le A, Ferrucci L, Moaddel R, de Cabo R, Hoke A, Walston J, Abadir PM. Westbrook R, et al. Among authors: de cabo r. JCI Insight. 2020 Aug 20;5(16):e136091. doi: 10.1172/jci.insight.136091. JCI Insight. 2020. PMID: 32814718 Free PMC article.
Of Greek heroes, wiggling worms, mighty mice, and old body builders.
Ferrucci L, de Cabo R, Knuth ND, Studenski S. Ferrucci L, et al. Among authors: de cabo r. J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):13-6. doi: 10.1093/gerona/glr046. Epub 2011 Nov 23. J Gerontol A Biol Sci Med Sci. 2012. PMID: 22113943 Free PMC article. No abstract available.
LKB1 and AMPK regulate synaptic remodeling in old age.
Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR. Samuel MA, et al. Among authors: de cabo r. Nat Neurosci. 2014 Sep;17(9):1190-7. doi: 10.1038/nn.3772. Epub 2014 Aug 3. Nat Neurosci. 2014. PMID: 25086610 Free PMC article.
Liver aging and pseudocapillarization in a Werner syndrome mouse model.
Cogger VC, Svistounov D, Warren A, Zykova S, Melvin RG, Solon-Biet SM, O'Reilly JN, McMahon AC, Ballard JW, De Cabo R, Le Couteur DG, Lebel M. Cogger VC, et al. Among authors: de cabo r. J Gerontol A Biol Sci Med Sci. 2014 Sep;69(9):1076-86. doi: 10.1093/gerona/glt169. Epub 2013 Oct 22. J Gerontol A Biol Sci Med Sci. 2014. PMID: 24149428 Free PMC article.
A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, Calvo-Rubio M, Deleyto-Seldas N, de Prado-Rivas L, Plata-Gómez AB, Fernández-Florido E, González-García P, Vivas-García Y, Sánchez García E, Graña-Castro O, Price NL, Aroca-Crevillén A, Caleiras E, Monleón D, Borrás C, Casanova-Acebes M, de Cabo R, Efeyan A. Ortega-Molina A, et al. Among authors: de cabo r. Nat Aging. 2024 Jun 7. doi: 10.1038/s43587-024-00635-x. Online ahead of print. Nat Aging. 2024. PMID: 38849535
369 results