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Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I.
Biochem Biophys Res Commun. 2019 Jun 30;514(3):974-978. doi: 10.1016/j.bbrc.2019.05.064. Epub 2019 May 12.
Biochem Biophys Res Commun. 2019.
PMID: 31092330
Free PMC article.
Highly resistant HIV-1 proteases and strategies for their inhibition.
Weber IT, Kneller DW, Wong-Sam A.
Weber IT, et al. Among authors: wong sam a.
Future Med Chem. 2015;7(8):1023-38. doi: 10.4155/fmc.15.44.
Future Med Chem. 2015.
PMID: 26062399
Free PMC article.
Review.
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Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.
Wong-Sam A, Wang YF, Zhang Y, Ghosh AK, Harrison RW, Weber IT.
Wong-Sam A, et al.
ACS Omega. 2018 Sep 30;3(9):12132-12140. doi: 10.1021/acsomega.8b01683. Epub 2018 Sep 27.
ACS Omega. 2018.
PMID: 30288468
Free PMC article.
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HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.
Wong-Sam A, Wang YF, Kneller DW, Kovalevsky AY, Ghosh AK, Harrison RW, Weber IT.
Wong-Sam A, et al.
J Mol Graph Model. 2022 Dec;117:108315. doi: 10.1016/j.jmgm.2022.108315. Epub 2022 Sep 1.
J Mol Graph Model. 2022.
PMID: 36108568
Free PMC article.
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Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation.
Ghosh AK, Mishevich JL, Kovela S, Shaktah R, Ghosh AK, Johnson M, Wang YF, Wong-Sam A, Agniswamy J, Amano M, Takamatsu Y, Hattori SI, Weber IT, Mitsuya H.
Ghosh AK, et al. Among authors: wong sam a.
Eur J Med Chem. 2023 Jul 5;255:115385. doi: 10.1016/j.ejmech.2023.115385. Epub 2023 Apr 21.
Eur J Med Chem. 2023.
PMID: 37150084
Free PMC article.
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Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection.
Young IC, Massud I, Cottrell ML, Shrivastava R, Maturavongsadit P, Prasher A, Wong-Sam A, Dinh C, Edwards T, Mrotz V, Mitchell J, Seixas JN, Pallerla A, Thorson A, Schauer A, Sykes C, De la Cruz G, Montgomery SA, Kashuba ADM, Heneine W, Dobard CW, Kovarova M, Garcia JV, García-Lerma JG, Benhabbour SR.
Young IC, et al. Among authors: wong sam a.
Nat Commun. 2023 Feb 9;14(1):708. doi: 10.1038/s41467-023-36330-5.
Nat Commun. 2023.
PMID: 36759645
Free PMC article.
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Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection.
Young IC, Massud I, Cottrell ML, Shrivastava R, Maturavongsadit P, Prasher A, Wong-Sam A, Dinh C, Edwards T, Mrotz V, Mitchell J, Seixas JN, Pallerla A, Thorson A, Schauer A, Sykes C, De la Cruz G, Montgomery SA, Kashuba ADM, Heneine W, Dobard CW, Kovarova M, Garcia JV, Garcίa-Lerma JG, Benhabbour SR.
Young IC, et al. Among authors: wong sam a.
Nat Commun. 2024 Feb 5;15(1):1054. doi: 10.1038/s41467-024-45552-0.
Nat Commun. 2024.
PMID: 38316836
Free PMC article.
No abstract available.
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Pharmacokinetic Study of Islatravir and Etonogestrel Implants in Macaques.
Daly MB, Wong-Sam A, Li L, Krovi A, Gatto GJ, Norton C, Luecke EH, Mrotz V, Forero C, Cottrell ML, Schauer AP, Gary J, Nascimento-Seixas J, Mitchell J, van der Straten A, Heneine W, García-Lerma JG, Dobard CW, Johnson LM.
Daly MB, et al. Among authors: wong sam a.
Pharmaceutics. 2023 Nov 26;15(12):2676. doi: 10.3390/pharmaceutics15122676.
Pharmaceutics. 2023.
PMID: 38140017
Free PMC article.
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