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Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.
Flores AM, Hosseini-Nassab N, Jarr KU, Ye J, Zhu X, Wirka R, Koh AL, Tsantilas P, Wang Y, Nanda V, Kojima Y, Zeng Y, Lotfi M, Sinclair R, Weissman IL, Ingelsson E, Smith BR, Leeper NJ. Flores AM, et al. Among authors: leeper nj. Nat Nanotechnol. 2020 Feb;15(2):154-161. doi: 10.1038/s41565-019-0619-3. Epub 2020 Jan 27. Nat Nanotechnol. 2020. PMID: 31988506 Free PMC article.
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.
Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T. Chun HJ, et al. Among authors: leeper nj. J Clin Invest. 2008 Oct;118(10):3343-54. doi: 10.1172/JCI34871. J Clin Invest. 2008. PMID: 18769630 Free PMC article.
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.
Leeper NJ, Raiesdana A, Kojima Y, Kundu RK, Cheng H, Maegdefessel L, Toh R, Ahn GO, Ali ZA, Anderson DR, Miller CL, Roberts SC, Spin JM, de Almeida PE, Wu JC, Xu B, Cheng K, Quertermous M, Kundu S, Kortekaas KE, Berzin E, Downing KP, Dalman RL, Tsao PS, Schadt EE, Owens GK, Quertermous T. Leeper NJ, et al. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):e1-e10. doi: 10.1161/ATVBAHA.112.300399. Epub 2012 Nov 15. Arterioscler Thromb Vasc Biol. 2013. PMID: 23162013 Free PMC article.
CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.
Nanda V, Downing KP, Ye J, Xiao S, Kojima Y, Spin JM, DiRenzo D, Nead KT, Connolly AJ, Dandona S, Perisic L, Hedin U, Maegdefessel L, Dalman J, Guo L, Zhao X, Kolodgie FD, Virmani R, Davis HR Jr, Leeper NJ. Nanda V, et al. Among authors: leeper nj. Circ Res. 2016 Jan 22;118(2):230-40. doi: 10.1161/CIRCRESAHA.115.307906. Epub 2015 Nov 23. Circ Res. 2016. PMID: 26596284 Free PMC article.
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.
Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. Kojima Y, et al. Among authors: leeper nj. Nature. 2016 Aug 4;536(7614):86-90. doi: 10.1038/nature18935. Epub 2016 Jul 20. Nature. 2016. PMID: 27437576 Free PMC article.
The Role of Efferocytosis in Atherosclerosis.
Kojima Y, Weissman IL, Leeper NJ. Kojima Y, et al. Among authors: leeper nj. Circulation. 2017 Jan 31;135(5):476-489. doi: 10.1161/CIRCULATIONAHA.116.025684. Circulation. 2017. PMID: 28137963 Free PMC article.
143 results