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Potent, specific MEPicides for treatment of zoonotic staphylococci.
Edwards RL, Heueck I, Lee SG, Shah IT, Miller JJ, Jezewski AJ, Mikati MO, Wang X, Brothers RC, Heidel KM, Osbourn DM, Burnham CD, Alvarez S, Fritz SA, Dowd CS, Jez JM, Odom John AR. Edwards RL, et al. Among authors: osbourn dm. PLoS Pathog. 2020 Jun 4;16(6):e1007806. doi: 10.1371/journal.ppat.1007806. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32497104 Free PMC article.
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: osbourn dm. J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24. J Med Chem. 2018. PMID: 30192536 Free PMC article.
Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB.
Mikati MO, Miller JJ, Osbourn DM, Barekatain Y, Ghebremichael N, Shah IT, Burnham CD, Heidel KM, Yan VC, Muller FL, Dowd CS, Edwards RL, Odom John AR. Mikati MO, et al. Among authors: osbourn dm. ACS Infect Dis. 2020 Nov 13;6(11):3064-3075. doi: 10.1021/acsinfecdis.0c00582. Epub 2020 Oct 29. ACS Infect Dis. 2020. PMID: 33118347 Free PMC article.
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Hasan MM, Stebbins EE, Choy RKM, Gillespie JR, de Hostos EL, Miller P, Mushtaq A, Ranade RM, Teixeira JE, Verlinde CLMJ, Sateriale A, Zhang Z, Osbourn DM, Griggs DW, Fan E, Buckner FS, Huston CD. Hasan MM, et al. Among authors: osbourn dm. Antimicrob Agents Chemother. 2021 May 18;65(6):e00023-21. doi: 10.1128/AAC.00023-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33753338 Free PMC article.
Determination of 8-oxoguanine and 8-hydroxy-2'-deoxyguanosine in the rat cerebral cortex using microdialysis sampling and capillary electrophoresis with electrochemical detection.
Arnett SD, Osbourn DM, Moore KD, Vandaveer SS, Lunte CE. Arnett SD, et al. Among authors: osbourn dm. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):16-25. doi: 10.1016/j.jchromb.2005.05.036. Epub 2005 Jul 1. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 15994136 Free PMC article.
On-line preconcentration methods for capillary electrophoresis.
Osbourn DM, Weiss DJ, Lunte CE. Osbourn DM, et al. Electrophoresis. 2000 Aug;21(14):2768-79. doi: 10.1002/1522-2683(20000801)21:14<2768::AID-ELPS2768>3.0.CO;2-P. Electrophoresis. 2000. PMID: 11001283 Free PMC article. Review.
MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase.
Wang X, Edwards RL, Ball HS, Heidel KM, Brothers RC, Johnson C, Haymond A, Girma M, Dailey A, Roma JS, Boshoff HI, Osbourn DM, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: osbourn dm. ACS Infect Dis. 2023 Jul 14;9(7):1387-1395. doi: 10.1021/acsinfecdis.3c00132. Epub 2023 Jun 13. ACS Infect Dis. 2023. PMID: 37310810