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A negative reciprocal regulatory axis between cyclin D1 and HNF4α modulates cell cycle progression and metabolism in the liver.
Wu H, Reizel T, Wang YJ, Lapiro JL, Kren BT, Schug J, Rao S, Morgan A, Herman A, Shekels LL, Rassette MS, Lane AN, Cassel T, Fan TWM, Manivel JC, Gunewardena S, Apte U, Sicinski P, Kaestner KH, Albrecht JH. Wu H, et al. Among authors: morgan a. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17177-17186. doi: 10.1073/pnas.2002898117. Epub 2020 Jul 6. Proc Natl Acad Sci U S A. 2020. PMID: 32631996 Free PMC article.
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.
Coate KC, Cha J, Shrestha S, Wang W, Gonçalves LM, Almaça J, Kapp ME, Fasolino M, Morgan A, Dai C, Saunders DC, Bottino R, Aramandla R, Jenkins R, Stein R, Kaestner KH, Vahedi G; HPAP Consortium; Brissova M, Powers AC. Coate KC, et al. Among authors: morgan a. Cell Metab. 2020 Dec 1;32(6):1028-1040.e4. doi: 10.1016/j.cmet.2020.11.006. Epub 2020 Nov 13. Cell Metab. 2020. PMID: 33207245 Free PMC article.
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes.
Fasolino M, Schwartz GW, Patil AR, Mongia A, Golson ML, Wang YJ, Morgan A, Liu C, Schug J, Liu J, Wu M, Traum D, Kondo A, May CL, Goldman N, Wang W, Feldman M, Moore JH, Japp AS, Betts MR; HPAP Consortium; Faryabi RB, Naji A, Kaestner KH, Vahedi G. Fasolino M, et al. Among authors: morgan a. Nat Metab. 2022 Feb;4(2):284-299. doi: 10.1038/s42255-022-00531-x. Epub 2022 Feb 28. Nat Metab. 2022. PMID: 35228745 Free PMC article.
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells.
Coate KC, Cha J, Shrestha S, Wang W, Gonçalves LM, Almaça J, Kapp ME, Fasolino M, Morgan A, Dai C, Saunders DC, Bottino R, Aramandla R, Jenkins R, Stein R, Kaestner KH, Vahedi G, Consortium H, Brissova M, Powers AC. Coate KC, et al. Among authors: morgan a. bioRxiv [Preprint]. 2020 Oct 20:2020.08.31.275719. doi: 10.1101/2020.08.31.275719. bioRxiv. 2020. PMID: 33106804 Free PMC article. Updated. Preprint.
Supporting self-management of low back pain with an internet intervention with and without telephone support in primary care (SupportBack 2): a randomised controlled trial of clinical and cost-effectiveness.
Geraghty AWA, Becque T, Roberts LC, Hill JC, Foster NE, Yardley L, Stuart B, Turner DA, Hay E, Griffiths G, Webley F, Durcan L, Morgan A, Hughes S, Bathers S, Butler-Walley S, Wathall S, Mansell G, White M, Davies F, Little P. Geraghty AWA, et al. Among authors: morgan a. Lancet Rheumatol. 2024 May 30:S2665-9913(24)00086-9. doi: 10.1016/S2665-9913(24)00086-9. Online ahead of print. Lancet Rheumatol. 2024. PMID: 38824934 Free article.
Oral estrogen receptor PROTAC® vepdegestrant (ARV-471) is highly efficacious as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models.
Gough SM, Flanagan JJ, Teh J, Andreoli M, Rousseau E, Pannone M, Bookbinder M, Willard R, Davenport K, Bortolon E, Cadelina G, Gordon D, Pizzano J, Macaluso J, Soto L, Corradi J, Digianantonio K, Drulyte I, Morgan A, Quinn C, Békés M, Ferraro C, Chen X, Wang G, Dong H, Wang J, Langley DR, Houston J, Gedrich R, Taylor IC. Gough SM, et al. Among authors: morgan a. Clin Cancer Res. 2024 May 31. doi: 10.1158/1078-0432.CCR-23-3465. Online ahead of print. Clin Cancer Res. 2024. PMID: 38819400
3,346 results