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103 results

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Synthetic nanobodies as angiotensin receptor blockers.
McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. McMahon C, et al. Among authors: kruse ac. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20284-20291. doi: 10.1073/pnas.2009029117. Epub 2020 Aug 4. Proc Natl Acad Sci U S A. 2020. PMID: 32753386 Free PMC article.
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. Shukla AK, et al. Among authors: kruse ac. Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21. Nature. 2013. PMID: 23604254 Free PMC article.
Covalent agonists for studying G protein-coupled receptor activation.
Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. Weichert D, et al. Among authors: kruse ac. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10744-8. doi: 10.1073/pnas.1410415111. Epub 2014 Jul 8. Proc Natl Acad Sci U S A. 2014. PMID: 25006259 Free PMC article.
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.
Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. Maute RL, et al. Among authors: kruse ac. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6506-14. doi: 10.1073/pnas.1519623112. Epub 2015 Nov 10. Proc Natl Acad Sci U S A. 2015. PMID: 26604307 Free PMC article.
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Staus DP, et al. Among authors: kruse ac. Nature. 2016 Jul 21;535(7612):448-52. doi: 10.1038/nature18636. Epub 2016 Jul 13. Nature. 2016. PMID: 27409812 Free PMC article.
Identification of the gene that codes for the σ2 receptor.
Alon A, Schmidt HR, Wood MD, Sahn JJ, Martin SF, Kruse AC. Alon A, et al. Among authors: kruse ac. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7160-7165. doi: 10.1073/pnas.1705154114. Epub 2017 May 30. Proc Natl Acad Sci U S A. 2017. PMID: 28559337 Free PMC article.
Structural Basis for G Protein-Coupled Receptor Signaling.
Erlandson SC, McMahon C, Kruse AC. Erlandson SC, et al. Among authors: kruse ac. Annu Rev Biophys. 2018 May 20;47:1-18. doi: 10.1146/annurev-biophys-070317-032931. Epub 2018 Mar 2. Annu Rev Biophys. 2018. PMID: 29498889
103 results