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Viewing rare conformations of the β2 adrenergic receptor with pressure-resolved DEER spectroscopy.
Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31824-31831. doi: 10.1073/pnas.2013904117. Epub 2020 Nov 30.
Proc Natl Acad Sci U S A. 2020.
PMID: 33257561
Free PMC article.
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor.
Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P.
Liu X, et al. Among authors: matt ra.
Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1.
Nat Chem Biol. 2020.
PMID: 32483378
Free PMC article.
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Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.
Thorsen TS, Matt R, Weis WI, Kobilka BK.
Thorsen TS, et al.
Structure. 2014 Nov 4;22(11):1657-64. doi: 10.1016/j.str.2014.08.022. Epub 2014 Oct 23.
Structure. 2014.
PMID: 25450769
Free PMC article.
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Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.
DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK.
DeVree BT, et al. Among authors: matt ra.
Nature. 2016 Jul 7;535(7610):182-6. doi: 10.1038/nature18324. Epub 2016 Jun 29.
Nature. 2016.
PMID: 27362234
Free PMC article.
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Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles.
Matt RA, Westhorpe FG, Romuar RF, Rana P, Gever JR, Ford AP.
Matt RA, et al.
Front Mol Biosci. 2023 Aug 17;10:1214102. doi: 10.3389/fmolb.2023.1214102. eCollection 2023.
Front Mol Biosci. 2023.
PMID: 37664183
Free PMC article.
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Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease.
Matt RA, Martin RS, Evans AK, Gever JR, Vargas GA, Shamloo M, Ford AP.
Matt RA, et al.
Handb Exp Pharmacol. 2023 Jul 27. doi: 10.1007/164_2023_677. Online ahead of print.
Handb Exp Pharmacol. 2023.
PMID: 37495851
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