Hajduk PJ - Search Results

1

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

Dietrich JD, Longenecker KL, Wilson NS, Goess C, Panchal SC, Swann SL, Petros AM, Hobson AD, Ihle D, Song D, Richardson P, Comess KM, Cox PB, Dombrowski A, Sarris K, Donnelly-Roberts DL, Duignan DB, Gomtsyan A, Jung P, Krueger AC, Mathieu S, McClure A, Stoll VS, Wetter J, Mankovich JA, Hajduk PJ, Vasudevan A, Stoffel RH, Sun C. Dietrich JD, et al. Among authors: hajduk pj. J Med Chem. 2021 Jan 14;64(1):417-429. doi: 10.1021/acs.jmedchem.0c01280. Epub 2020 Dec 30. J Med Chem. 2021. PMID: 33378180

2

Biochemical and biophysical characterization of unique switch pocket inhibitors of p38α.

Swann SL, Merta PJ, Kifle L, Groebe D, Sarris K, Hajduk PJ, Sun C. Swann SL, et al. Among authors: hajduk pj. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5787-92. doi: 10.1016/j.bmcl.2010.04.097. Epub 2010 Apr 28. Bioorg Med Chem Lett. 2010. PMID: 20471255

3

A unified, probabilistic framework for structure- and ligand-based virtual screening.

Swann SL, Brown SP, Muchmore SW, Patel H, Merta P, Locklear J, Hajduk PJ. Swann SL, et al. Among authors: hajduk pj. J Med Chem. 2011 Mar 10;54(5):1223-32. doi: 10.1021/jm1013677. Epub 2011 Feb 10. J Med Chem. 2011. PMID: 21309579

4

Labeled Ligand Displacement: Extending NMR-Based Screening of Protein Targets.

Swann SL, Song D, Sun C, Hajduk PJ, Petros AM. Swann SL, et al. Among authors: hajduk pj. ACS Med Chem Lett. 2010 Jun 24;1(6):295-9. doi: 10.1021/ml1000849. eCollection 2010 Sep 9. ACS Med Chem Lett. 2010. PMID: 24900211 Free PMC article.

5

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ. Huth JR, et al. Among authors: hajduk pj. J Med Chem. 2004 Sep 23;47(20):4851-7. doi: 10.1021/jm0497803. J Med Chem. 2004. PMID: 15369388

6

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.

Petros AM, Dinges J, Augeri DJ, Baumeister SA, Betebenner DA, Bures MG, Elmore SW, Hajduk PJ, Joseph MK, Landis SK, Nettesheim DG, Rosenberg SH, Shen W, Thomas S, Wang X, Zanze I, Zhang H, Fesik SW. Petros AM, et al. Among authors: hajduk pj. J Med Chem. 2006 Jan 26;49(2):656-63. doi: 10.1021/jm0507532. J Med Chem. 2006. PMID: 16420051

7

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.

Petros AM, Huth JR, Oost T, Park CM, Ding H, Wang X, Zhang H, Nimmer P, Mendoza R, Sun C, Mack J, Walter K, Dorwin S, Gramling E, Ladror U, Rosenberg SH, Elmore SW, Fesik SW, Hajduk PJ. Petros AM, et al. Among authors: hajduk pj. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. doi: 10.1016/j.bmcl.2010.09.033. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20870405

8

Fragment-based lead discovery: challenges and opportunities.

Sun C, Petros AM, Hajduk PJ. Sun C, et al. Among authors: hajduk pj. J Comput Aided Mol Des. 2011 Jul;25(7):607-10. doi: 10.1007/s10822-011-9451-z. Epub 2011 Jul 6. J Comput Aided Mol Des. 2011. PMID: 21732249

9

Design of adenosine kinase inhibitors from the NMR-based screening of fragments.

Hajduk PJ, Gomtsyan A, Didomenico S, Cowart M, Bayburt EK, Solomon L, Severin J, Smith R, Walter K, Holzman TF, Stewart A, McGaraughty S, Jarvis MF, Kowaluk EA, Fesik SW. Hajduk PJ, et al. J Med Chem. 2000 Dec 14;43(25):4781-6. doi: 10.1021/jm000373a. J Med Chem. 2000. PMID: 11123986

10

Utilization of NMR-derived fragment leads in drug design.

Huth JR, Sun C, Sauer DR, Hajduk PJ. Huth JR, et al. Among authors: hajduk pj. Methods Enzymol. 2005;394:549-71. doi: 10.1016/S0076-6879(05)94023-8. Methods Enzymol. 2005. PMID: 15808237

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

89 results

Search Page