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The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes.
Diabetes Care. 2021 Apr;44(4):960-968. doi: 10.2337/dc20-2684. Epub 2021 Feb 23.
Diabetes Care. 2021.
PMID: 33622669
Free PMC article.
Clinical Trial.
Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator.
Vella A, Freeman JLR, Dunn I, Keller K, Buse JB, Valcarce C.
Vella A, et al. Among authors: freeman jlr.
Sci Transl Med. 2019 Jan 16;11(475):eaau3441. doi: 10.1126/scitranslmed.aau3441.
Sci Transl Med. 2019.
PMID: 30651321
Clinical Trial.
Item in Clipboard
Impact of the hepatoselective glucokinase activator TTP399 on ketoacidosis during insulin withdrawal in people with type 1 diabetes.
Klein KR, Boeder SC, Freeman JLR, Dunn I, Dvergsten C, Madduri S, Giovannetti ER, Valcarce C, Buse JB, Pettus JH.
Klein KR, et al. Among authors: freeman jlr.
Diabetes Obes Metab. 2022 Aug;24(8):1439-1447. doi: 10.1111/dom.14697. Epub 2022 Jun 4.
Diabetes Obes Metab. 2022.
PMID: 35661378
Free PMC article.
Clinical Trial.
Item in Clipboard
Serum 1,5-anhydroglucitol (GlycoMark ): a short-term glycemic marker.
Buse JB, Freeman JL, Edelman SV, Jovanovic L, McGill JB.
Buse JB, et al.
Diabetes Technol Ther. 2003;5(3):355-63. doi: 10.1089/152091503765691839.
Diabetes Technol Ther. 2003.
PMID: 12828817
Item in Clipboard
Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years.
Wilding JP, Woo V, Rohwedder K, Sugg J, Parikh S; Dapagliflozin 006 Study Group.
Wilding JP, et al.
Diabetes Obes Metab. 2014 Feb;16(2):124-36. doi: 10.1111/dom.12187. Epub 2013 Aug 29.
Diabetes Obes Metab. 2014.
PMID: 23911013
Clinical Trial.
Item in Clipboard
Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial.
Wilding JP, Woo V, Soler NG, Pahor A, Sugg J, Rohwedder K, Parikh S; Dapagliflozin 006 Study Group.
Wilding JP, et al.
Ann Intern Med. 2012 Mar 20;156(6):405-15. doi: 10.7326/0003-4819-156-6-201203200-00003.
Ann Intern Med. 2012.
PMID: 22431673
Free article.
Clinical Trial.
Item in Clipboard
Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
Freeman JL, Gonzalo P, Pitcher JA, Claing A, Lavergne JP, Reboud JP, Lefkowitz RJ.
Freeman JL, et al.
Biochemistry. 2002 Oct 22;41(42):12850-7. doi: 10.1021/bi020145d.
Biochemistry. 2002.
PMID: 12379128
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